Utrecht Center for Diagnostic Advances in Immunology Research

U-DAIR aims to accelerate and improve immunology research and diagnostics

The Utrecht Center for Diagnostic Advances in Immunology Research
(U-DAIR) provides an extensive Immune Monitoring platform to study immunological parameters in patients with immune-mediated diseases and to assess the effects of immune modulatory treatment. Harmonised and standardised application of diagnostic and state-of-the-art research methodologies enable validated biomarker research and comparison of biomarker profiles between patient cohorts. Upon request we develop, optimise and validate analytical tests to facilitate research on disease-specific parameters.

Core Competences

  • High throughput quantification of (adipo) cytokines, chemokines and growth factors in multiplex assays (160+ analytes in 250 uL biological fluid)
  • Extensive phenotyping of leukocytes (e.g. T, B and NK(T) cell lymphocyte subsets) using flow cytometry
  • Functional assays on cytotoxicity and assessment of intracellular cytokine profiles in (un)stimulated lymphocytes
  • Assessment of allergenicity and patient allergic phenotypes by Basophil ActivationTest (BAT) 
  • HLA-typing, SNP analyses, TCR- and IG-sequencing using next generation sequencing
  • Pharmacological screening for immunological parameters and PK-PD modeling.
  • Development and validation of novel immunoassays, including immunoassays for biologicals
  • Access to generic diagnostic services for immunological parameters in Autoimmune diseases, Allergy, Transplant Immunology, Immune deficiencies, Oncology, Hematological malignancies, and Acute & Chronic Inflammation
  • Access to certified laboratory analysis: ISO9001, EFI, CCKL

U-DAIR is positioned within the diagnostic department of the Laboratory of Translational Immunology (LTI), UMC Utrecht.

read more:
Interview with Steven Nierkens

Contact

Stefan Nierkens
Utrecht Center for Diagnostic Advances In Immunology Research
UMC Utrecht
Sectie Diagnostiek LTI, U-DAIR
Heidelberglaan 100
3584 CX Utrecht

Phone: +31 6 3304 8039
Email: s.nierkens@umcutrecht.nl
Website: 

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