Intrahepatic cholangiocyte organoids for bile-duct tissue engineering and disease modeling
Zhenguo Wang
What was your PhD about?
"To understand the pathogenesis of cholangiopathies is crucial for the development of new therapeutic strategies for which suitable models are needed. During my PhD, I focused on tissue engineered bile duct and disease modeling. My research can be divided into three categories. 1. The culture of liver organoids in animal-free media. 2. Development of a bile duct on-a-chip. 3. Modeling cholangiopathy in vitro.
In conclusion, we developed a step-wise culture system for cholangiocytes, and established a bioengineered bile duct that can recapitulate key structures and functions of cholangiocytes for applications in biliary pathophysiological research and as alternative to animals in drug development studies."
What is your fondest memory of your time at RMU?
"Reflecting on my PhD journey, I have many wonderful memories at RMCU. My fondest memories of RMCU include the vibrant research atmosphere and collaborations in different fields. I will never forget my presentation, where I received a lot of encouragement and support at RMCU."
What are you going to do next?
"I am currently seeking a new job. If given the opportunity, I am eager to continue my career in academic research. During my PhD research, I recognized the power of organoids for drug screening and disease modeling. Therefore, I am passionate about continuing to work on organoids, utilizing them for drug screening and disease modeling."