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Simon van de Wakker

What was your PhD about? 

"The 15th of December, Simon van de Wakker defends his thesis titled “Extracellular Vesicle Heterogeneity and its Translational Implications for Cardiac Repair”. In this thesis, key challenges in translating extracellular vesicles (EV) therapeutics in the context of cardiac repair are addressed. This work encompasses multiple key-steps with a focus on enhancing EV functional delivery, purification, preservation, and understanding their functional heterogeneity. The work highlights the potential of EV-liposome hybrid nanoparticles for delivering therapeutic compounds. Furthermore, scalable EV isolation methods are described, as well as ways to improve EV stability during concentration and storage. The thesis also delves into EV heterogeneity, revealing differences in properties and functionality among EV subpopulations regarding cardiac regeneration. Collectively, these findings provide valuable insights for advancing EV-based therapeutics. By addressing multiple challenges, this work may contribute to the clinical translation of EVs to stimulate cardiac repair."

What is your fondest memory of your time at RMU?  

"My fondest memories of my time at the RMU were all the nice borrels and retreats which introduced me to a lot of great people!"  

What are you going to do next?  

"I am working now as a medical science liaison at Bayer."