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We aim to unravel the complex process of how endo-lysosomal system is built, maintained, and interacts with other organelles in health and disease. These insights could unlock new strategies to treat cancer, metabolic disorders, and neurodegenerative diseases.

Together, as the Klumperman Lab and Liv Lab, we merge methodological innovation with deep biological insight. Our joint research spans endo-lysosomal biology, inter-organelle communication, autophagy, cancer biology, and neuronal systems—bridging fundamental discovery with translational applications to tackle some of the most pressing biomedical challenges today.

The Klumperman Lab

We bring world-leading expertise in lysosome biology, membrane trafficking, and neuronal cell biology. Lysosomes are essential organelles that regulate cellular metabolism as well as some of the major signaling pathways in the cell, making them a key target for our research. Given the involvement of lysosomes in diseases like cancer and neurodegenerative disorders, our research is crucial for understanding and potentially treating these conditions.  Using state-of-the-art electron microscopy (EM), immuno-EM, and correlative light and electron microscopy (CLEM), we directly link live-cell dynamics to ultrastructural detail. This allows us to study how lysosomes integrate into the broader organelle network to regulate cellular metabolism and signaling in both healthy and diseased cells.

The Liv Lab 

We combine molecular and cellular biology, biochemistry, proteomics, and advanced imaging to dissect organelle function from multiple dimensions. This powerful, integrative approach connects molecular mechanisms with ultrastructural changes, revealing how the endolysosomal system communicates with and regulates other organelles. By developing and applying cutting-edge microscopy technologies, we visualize these interactions in unprecedented detail, identifying structural and molecular alterations linked to cancer, metabolic disorders, and other pathologies.

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