Developmental Biology

The research of the Developmental Biology division focuses on studying biological principles in the context of living, developing multicellular organisms. The division is led by Prof. Dr. Mike Boxem, and is home to several research groups, each with their own research focus. For an overview of our research, visit our research page.

Contact

Mike Boxem
+31 30 253 3714
m.boxem@uu.nl
Padualaan 8
3584 CH Utrecht
The Netherlands

BIOLOGY OFFICE
Phone: +31 30 253 3084
Email: biologyoffice@uu.nl

Contact

Research Groups

  • Our research focuses on the coordinated regulation of cell division and differentiation in the context of animal development. Visit this link for a .

  • We study the molecular mechanisms that underlie cell polarity using a combination of high-throughput protein interaction mapping approaches and in vivo studies using the model organism C. elegans.

  • Our lab develops new data science and bioinformatics methods to analyse data from quantitative (epi)genomics technologies and applies them to understand cell fate decisions.

  • We use stem cell-based embryo models (such as gastruloids) together with (single-cell) genomics, advanced microscopy, and reporter assays to study how gene regulation drives inter-tissue communication. Understanding the cross-talk between developing organs is a milestone towards the generation of organs in vitro for regenerative medicine.

  • We focus on how translational regulation contributes to cellular behavior and developmental decisions, using a combination of genetic, biochemical and single molecule imaging approaches.

  • We use 3D organoid co-cultures to integrate quantitative imaging, cell biology and biochemistry to study how cell competition is regulated and how misregulation of this process can lead to disease.

  • Reproduction is one of the major biological processes characteristic of all living species. In animals, sexual reproduction is the by far dominating mode of reproduction, although only half of the individuals (i.e. mothers) produce offspring.