PhD Defense: Inflammatory pathways and predictive biomarkers in sarcoidosis
PhD Defense of Raisa Kraaijvanger
Around 10 to 30% of the patients with sarcoidosis require treatment to alleviate symptoms or prevent organ damage. Besides having a heterogeneous and often unpredictable disease course, sarcoidosis patients can also vary in their response to the treatment. Therefore a one-size-fits-all approach can result in toxicity with unpredictable therapeutic response in some patients.
As a result, there is a need for more specific and predictive biomarkers to improve clinical management. In this thesis, we aimed to pave the way for precision medicine for sarcoidosis care by identifying novel predictive or therapeutic biomarkers in form of proteins or signaling pathways. We will review the current literature on predictive biomarkers in sarcoidosis and examine extracellular vesicles as potential new biomarker source.
In addition, the role of inflammatory signaling pathways as biomarker is explored, as well as its potential as guiding the choice of forth-line therapy in the future.
- Start date and time
- End date and time
- Location
- PhD candidate
- R. Kraaijvanger
- Dissertation
- Inflammatory pathways and predictive biomarkers in sarcoidosis
- PhD supervisor(s)
- prof. dr. J.C. Grutters
- Co-supervisor(s)
- dr. M. Veltkamp
- dr. C.H.M. van Moorsel
- More information