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PLEASE NOTE: If a candidate gives a layman's talk, the livestream will start fifteen minutes earlier.

Medicines need a way to reach the right place in the body to work efficiently and safely, but natural barriers such as stomach acid, digestive enzymes, and protective membranes often prevent this, while many drugs also break down too quickly. To overcome these problems, drug delivery systems are designed to protect medicines, control their release, and improve absorption. Conventional carriers like nanoparticles, liposomes, or hydrogels can help, but often suffer from low loading, rapid release, or poor targeting.

My research explored antibubbles as a new approach. Unlike regular bubbles filled with air, antibubbles have liquid cores wrapped in a thin air shell, with nanoparticles on their surfaces to stabilize them. This unique structure prevents premature leakage and allows controlled, trigger-based release in response to factors such as pH, bile salts, or enzymes.

In this thesis, I developed acid-responsive antibubbles for stomach delivery, bile salt-triggered antibubbles carrying daunorubicin for intestinal release, triple-emulsion antibubbles that can hold both water- and fat-soluble drugs, a gentler production method (premix membrane emulsification) for sensitive compounds, and dual-drug systems stabilized with prednisolone-loaded nanoparticles while carrying mesalamine in their cores. These studies highlight antibubbles as promising carriers for safer, more effective, and targeted oral therapies.