Prof. dr. G. (Gestur) Vidarsson
Professor
Recent highlight publications of the last 5 years
1. Van Osch TLJ, Oosterhoff JJ, Bentlage AEH, Nouta J, Koeleman CAM, Geerdes DM, Mok JY, Heidt S, Mulder A, Van Esch WJE, Kapur R, Porcelijn L, Van der Schoot CE, De Haas M, Wuhrer M, Voorberg J, Vidarsson G. Fc galactosylation of anti-platelet hIgG1 alloantibodies enhance complement activation on platelets.
Haematologica. 2022 Mar 31. doi: 10.3324/haematol.2021.280493. In press
2. Hviid L, Lopez-Perez M, Larsen MD, Vidarsson G. No sweet deal: the antibody-mediated immune response to malaria.
Trends Parasitol. 2022 Mar 9:S1471-4922(22)00038-1. doi: 10.1016/j.pt.2022.02.008.
3. Brinkhaus M, van der Kooi EJ, Bentlage AEH, Ooijevaar-de Heer P, Derksen NIL, Rispens T, Vidarsson G. Human IgE does not bind to human FcRn.
Sci Rep. 2022 Jan 7;12(1):62. doi: 10.1038/s41598-021-03852-1. 2
4. Wojcik I, Schmidt DE, de Neef LA, Rab MAE, Meek B, de Weerdt O, Wuhrer M, van der Schoot CE, Zwaginga JJ, de Haas M, Falck D, Vidarsson G. A functional spleen contributes to afucosylated IgG in humans.
Sci Rep. 2021;11(1):24045. doi: 10.1038/s41598-021-03196-w
5. Larsen MD, Lopez-Perez M, Dickson EK, Ampomah P, Ndam NT, Nouta J, Koeleman CAM, Hipgrave Ederveen AL, Mordmüller B, Salanti A, Nielsen MA, Massougbodji A, van der Schoot CE, Ofori MF, Wuhrer M, Hviid L & Vidarsson G: Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination.
Nature Communications 2021; 12:5838. DOI 10.1038/s41467-021-26118-w
6. Wolfe GI, Ward ES, de Haard H, Ulrichts P, Mozaffar T, Pasnoor M, Vidarsson G. IgG regulation through FcRn blocking: A novel mechanism for the treatment of myasthenia gravis.
J Neurol Sci. 2021;430:118074. doi: 10.1016/j.jns.2021.118074.
7. van Osch TLJ, Nouta J, Derksen NIL, van Mierlo G, van der Schoot CE, Wuhrer M, Rispens T, Vidarsson G. Fc Galactosylation Promotes Hexamerization of Human IgG1, Leading to Enhanced Classical Complement Activation.
J Immunol. 2021;207(6):1545-1554. doi: 10.4049/jimmunol.2100399.
8. Boekel L, Steenhuis M, Hooijberg F, Besten YR, van Kempen ZLE, Kummer LY, van Dam KPJ, Stalman EW, Vogelzang EH, Cristianawati O, Keijzer S, Vidarsson G, Voskuyl AE, Wieske L, Eftimov F, van Vollenhoven R, Kuijpers TW, van Ham SM, Tas SW, Killestein J, Boers M, Nurmohamed MT, Rispens T, Wolbink G. Antibody development after COVID-19 vaccination in patients with autoimmune diseases in the Netherlands: a substudy of data from two prospective cohort studies.
Lancet Rheumatol. 2021. doi: 10.1016/S2665-9913(21)00222-8.
9. Bye AP, Hoepel W, Mitchell JL, Jégouic SM, Loureiro S, Sage T, Vidarsson G, Nouta J, Wuhrer M, de Taeye SW, van Gils M, Kriek N, Cooper N, Jones I, den Dunnen J, Gibbins JM. Aberrant glycosylation of anti-SARS-CoV-2 IgG is a pro-thrombotic stimulus for platelets.
Blood. 2021;238(16):1481-9 doi: 10.1182/blood.2021011871.
10. Zwarthoff SA, Widmer K, Kuipers A, Strasser J, Ruyken M, Aerts PC, de Haas CJC, Ugurlar D, den Boer MA, Vidarsson G, van Strijp JAG, Gros P, Parren PWHI, van Kessel KPM, Preiner J, Beurskens FJ, Schuurman J, Ricklin D, Rooijakkers SHM. C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases.
Proc Natl Acad Sci U S A. 2021;118(26):e2102787118. doi: 10.1073/pnas.2102787118
11. Braster R, Bögels M, Benonisson H, Wuhrer M, Plomp R, Bentlage AEH, Korthouwer R, Visser R, Verbeek JS, van Egmond M, Vidarsson G. Afucosylated IgG Targets FcγRIV for Enhanced Tumor Therapy in Mice.
Cancers (Basel). 2021 May 14;13(10):2372. doi: 10.3390/cancers13102372.
12. Hoepel W, Chen HJ, Geyer CE, Allahverdiyeva S, Manz XD, de Taeye SW, Aman J, Mes L, Steenhuis M, Griffith GR, Bonta PI, Brouwer PJM, Caniels TG, van der Straten K, Golebski K, Jonkers RE, Larsen MD, Linty F, Nouta J, van Roomen CPAA, van Baarle FEHP, van Drunen CM, Wolbink G, Vlaar APJ, de Bree GJ, Sanders RW, Willemsen L, Neele AE, van de Beek D, Rispens T, Wuhrer M, Bogaard HJ, van Gils MJ, Vidarsson G, de Winther M, den Dunnen J. High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages.
Sci Transl Med. 2021; 13(596):eabf8654. doi: 10.1126/scitranslmed.abf8654.
13. Temming AR, Tammes Buirs M, Bentlage AEH, Treffers LW, Feringa H, de Taeye SW, Kuijpers TW, Nagelkerke SQ, Brasser G, Mok JY, van Esch WJE, van den Berg TK, Rispens T, van der Schoot CE, Vidarsson G. C-Reactive Protein Enhances IgG-Mediated Cellular Destruction Through IgG-Fc Receptors in vitro.
Front Immunol. 2021;12:594773. doi: 10.3389/fimmu.2021.594773.
14. Heemskerk N, Gruijs M, Temming AR, Heineke MH, Gout DY, Hellingman T, Tuk CW, Winter PJ, Lissenberg-Thunnissen S, Bentlage AE, De Donatis M, Bögels M, Rösner T, Valerius T, Bakema JE, Vidarsson G, van Egmond M. Augmented antibody-based anti-cancer therapeutics boost neutrophil cytotoxicity.
J Clin Invest. 2021 Feb 9:134680. doi: 10.1172/JCI134680.
15. Larsen MD, de Graaf EL, Sonneveld ME, Plomp HR, Nouta J, Hoepel W, Chen HJ, Linty F, Visser R, Brinkhaus M, Šuštic T, de Taeye SW, Bentlage AEH, Toivonen S, Koeleman CAM, Sainio S, Kootstra NA, Brouwer PJM, Geyer CE, Derksen NIL, Wolbink G, de Winther M, Sanders RW, van Gils MJ, de Bruin S, Vlaar APJ; Amsterdam UMC COVID-19 biobank study group, Rispens T, den Dunnen J, Zaaijer HL, Wuhrer M, Ellen van der Schoot C, Vidarsson G. Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity.
Science. 2021;371(6532):eabc8378. doi: 10.1126/science.abc8378.
16. Brinkhaus M, Douwes RGJ, Bentlage AEH, Temming AR, de Taeye SW, Tammes Buirs M, Gerritsen J, Mok JY, Brasser G, Ligthart PC, van Esch WJE, Verheesen P, de Haard H, Rispens T, Vidarsson G. Glycine 236 in the Lower Hinge Region of Human IgG1 Differentiates FcγR from Complement Effector Function.
J Immunol. 2020;205(12):3456-3467. doi: 10.4049/jimmunol.2000961.
17. Brouwer PJM, Caniels TG, van der Straten K, Snitselaar JL, Aldon Y, Bangaru S, Torres JL, Okba NMA, Claireaux M, Kerster G, Bentlage AEH, van Haaren MM, Guerra D, Burger JA, Schermer EE, Verheul KD, van der Velde N, van der Kooi A, van Schooten J, van Breemen MJ, Bijl TPL, Sliepen K, Aartse A, Derking R, Bontjer I, Kootstra NA, Wiersinga WJ, Vidarsson G, Haagmans BL, Ward AB, de Bree GJ, Sanders RW, van Gils MJ:Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability.
Science. 2020;369(6504):643-650. doi: 10.1126/science.abc5902.
18. de Taeye SW, Bentlage AEH, Mebius MM, Meesters JI, Lissenberg-Thunnissen S, Falck D, Sénard T, Salehi N, Wuhrer M, Schuurman J, Labrijn AF, Rispens T, Vidarsson G: FcγR Binding and ADCC Activity of Human IgG Allotypes.
Front Immunol. 2020 May 6;11:740. doi: 10.3389/fimmu.2020.00740. eCollection 2020.
19. Temming AR, de Taeye SW, de Graaf EL, de Neef LA, Dekkers G, Bruggeman CW, Koers J, Ligthart P, Nagelkerke SQ, Zimring JC, Kuijpers TW, Wuhrer M, Rispens T, Vidarsson G. Functional Attributes of Antibodies, Effector Cells, and Target Cells Affecting NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity.
Journal of Immunology 2019;203(12):3126-3135. doi: 10.4049/jimmunol.1900985.
20. Temming AR, Dekkers G, van de Bovenkamp FS, Plomp HR, Bentlage AEH, Szittner Z, Derksen NIL, Wuhrer M, Rispens T, Vidarsson G: Human DC-SIGN and CD23 do not interact with human IgG.
Scientific Reports 2019;9(1):9995. doi: 10.1038/s41598-019-46484-2.
21. De Taeye SW, Rispens T, Vidarsson G: The Ligands for Human IgG and Their Effector Functions.
Antibodies 2019, 8(2), 30. Doi: 10.3390/antib8020030
22. van de Bovenkamp FS, Derksen NIL, Ooijevaar-de Heer P, van Schie KA, Kruithof S, Berkowska MA, van der Schoot CE, IJspeert H, van der Burg M, Gils A, Hafkenscheid L, Toes REM, Rombouts Y, Plomp R, Wuhrer M, van Ham SM, Vidarsson G and Rispens T. Adaptive antibody diversification through N-linked glycosylation of the immunoglobulin variable region
PNAS 2018;115(8):1901-1906
23. Dekkers G, Treffers L, Plomp R, Bentlage AEH, de Boer M, Koeleman CAM, Lissenberg-Thunnissen SN, Visser R, Brouwer M, Mok JY, Matlung H, van den Berg TK, van Esch WJE, Kuijpers TW, Wouters D, Rispens T, Wuhrer M, Vidarsson G. Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities.
Frontiers in Immunology. 2017;8:877
24. Stegmann TC, Veldhuisen B, Nagelkerke SQ, Winkelhorst D, Schonewille H, Verduin EP, Kuijpers TW, de Haas M, Vidarsson G, van der Schoot CE. RhIg-prophylaxis is not influenced by FCGR2/3 polymorphisms involved in red blood cell clearance.
Blood 2017;129(8):1045-1048.
Publications
2023
Scholarly publications
Volkov, M., Brinkhaus, M., van Schie, K. A., Bondt, A., Kissel, T., van der Kooi, E. J., Bentlage, A. E. H., Koeleman, C. A. M., de Taeye, S. W., Derksen, N. I., Dolhain, R. J. E. M., Braig-Scherer, U., Huizinga, T. W. J., Wuhrer, M., Toes, R. E. M., Vidarsson, G., & van der Woude, D. (2023). IgG Fab Glycans Hinder FcRn-Mediated Placental Transport. Journal of Immunology, 210(2), 158-167.
Fatebenefratelli-Sacco Infectious Diseases Physicians group, & UMC COVID-19 S3/HCW study group (2023). The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees. EBioMedicine, 87, [104408].
van Osch, T. L. J., Steuten, J., Nouta, J., Koeleman, C. A. M., Bentlage, A. E. H., Heidt, S., Mulder, A., Voorberg, J., van Ham, S. M., Wuhrer, M., ten Brinke, A., & Vidarsson, G. (2023). Phagocytosis of platelets opsonized with differently glycosylated anti-HLA hIgG1 by monocyte-derived macrophages. Platelets, 34(1), [2129604].
Dingess, K. A., Hoek, M., van Rijswijk, D. M. H., Tamara, S., den Boer, M. A., Veth, T., Damen, M. J. A., Barendregt, A., Romijn, M., Juncker, H. G., van Keulen, B. J., Vidarsson, G., van Goudoever, J. B., Bondt, A., & Heck, A. J. R. (2023). Identification of common and distinct origins of human serum and breastmilk IgA1 by mass spectrometry-based clonal profiling. Cellular and Molecular Immunology, 1-12.
2022
Scholarly publications
Oskam, N., Ooijevaar-de Heer, P., Derksen, N. I. L., Kruithof, S., de Taeye, S. W., Vidarsson, G., Reijm, S., Kissel, T., Toes, R. E. M., & Rispens, T. (2022). At Critically Low Antigen Densities, IgM Hexamers Outcompete Both IgM Pentamers and IgG1 for Human Complement Deposition and Complement-Dependent Cytotoxicity. Journal of Immunology, 209(1), 16-25.
Maho-Vaillant, M., Sips, M., Golinski, M-L., Vidarsson, G., Goebeler, M., Stoevesandt, J., Bata-Cs枚rg艖, Z., Balbino, B., Verheesen, P., Joly, P., Hertl, M., & Calbo, S. (2022). FcRn Antagonism Leads to a Decrease of Desmoglein-Specific B Cells: Secondary Analysis of a Phase 2 Study of Efgartigimod in Pemphigus Vulgaris and Pemphigus Foliaceus. Frontiers in Immunology, 13, 863095.
Schriek, A. I., van Haaren, M. M., Poniman, M., Dekkers, G., Bentlage, A. E. H., Grobben, M., Vidarsson, G., Sanders, R. W., Verrips, T., Geijtenbeek, T. B. H., Heukers, R., Kootstra, N. A., de Taeye, S. W., & van Gils, M. J. (2022). Anti-HIV-1 Nanobody-IgG1 Constructs With Improved Neutralization Potency and the Ability to Mediate Fc Effector Functions. Frontiers in Immunology, 13, 893648.
Ward, E. S., Gelinas, D., Dreesen, E., Van Santbergen, J., Andersen, J. T., Silvestri, N. J., Kiss, J. E., Sleep, D., Rader, D. J., Kastelein, J. J. P., Louagie, E., Vidarsson, G., & Spriet, I. (2022). Clinical Significance of Serum Albumin and Implications of FcRn Inhibitor Treatment in IgG-Mediated Autoimmune Disorders. Frontiers in Immunology, 13, 892534.
Streng, B. M. M., Bont, M., Delemarre, E. M., Binnendijk, R. S., Smit, G., den Hartog, G., Coppus, A. M. W., de Vries, E., Weijerman, M. E., Lamberts, R., de Graaf, G., van der Klis, F. R., Vidarsson, G., Rave, N., Bont, L. J., & Wildenbeest, J. G. (2022). Decreased Antibody Response After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Patients With Down Syndrome. Journal of Infectious Diseases, 226(4), 673-677.
Cruz, A. R., Bentlage, A. E. H., Blonk, R., de Haas, C. J. C., Aerts, P. C., Scheepmaker, L. M., Bouwmeester, I. G., Lux, A., van Strijp, J. A. G., Nimmerjahn, F., van Kessel, K. P. M., Vidarsson, G., & Rooijakkers, S. H. M. (2022). Toward Understanding How Staphylococcal Protein A Inhibits IgG-Mediated Phagocytosis. Journal of Immunology, 209(6), 1146-1155.
Gst枚ttner, C., Knaupp, A., Vidarsson, G., Reusch, D., Schlothauer, T., Wuhrer, M., & Dom铆nguez-Vega, E. (2022). Affinity capillary electrophoresis - mass spectrometry permits direct binding assessment of IgG and Fc纬RIIa in a glycoform-resolved manner. Frontiers in Immunology, 13, 980291.
Brinkhaus, M., Pannecoucke, E., van der Kooi, E. J., Bentlage, A. E. H., Derksen, N. I. L., Andries, J., Balbino, B., Sips, M., Ulrichts, P., Verheesen, P., de Haard, H., Rispens, T., Savvides, S. N., & Vidarsson, G. (2022). The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement. Nature Communications, 13(1), [6073].
Van Coillie, J., Schulz, M. A., Bentlage, A. E. H., de Haan, N., Ye, Z., Geerdes, D. M., van Esch, W. J. E., Hafkenscheid, L., Miller, R. L., Narimatsu, Y., Vakhrushev, S. Y., Yang, Z., Vidarsson, G., & Clausen, H. (2022). Role of N-Glycosylation in Fc纬RIIIa interaction with IgG. Frontiers in Immunology, 13, [987151].
艩u拧ti膰, T., Van Coillie, J., Larsen, M. D., Derksen, N. I. L., Szittner, Z., Nouta, J., Wang, W., Damelang, T., Rebergen, I., Linty, F., Visser, R., Mok, J. Y., Geerdes, D. M., van Esch, W. J. E., de Taeye, S. W., van Gils, M. J., van de Watering, L., van der Schoot, C. E., Wuhrer, M., ... Vidarsson, G. (2022). Immunoassay for quantification of antigen-specific IgG fucosylation. EBioMedicine, 81, [104109].
van Osch, T. L. J., Pongracz, T., Geerdes, D. M., Mok, J. Y., van Esch, W. J. E., Voorberg, J., Kapur, R., Porcelijn, L., Kerkhoffs, J. L. H., van der Meer, P. F., van der Schoot, C. E., de Haas, M., Wuhrer, M., & Vidarsson, G. (2022). Altered Fc glycosylation of anti-HLA alloantibodies in hemato-oncological patients receiving platelet transfusions. Journal of Thrombosis and Haemostasis, 20(12), 3011-3025.
Oosterhoff, J. J., Larsen, M. D., van der Schoot, C. E., & Vidarsson, G. (2022). Afucosylated IgG responses in humans 鈥� structural clues to the regulation of humoral immunity. Trends in Immunology, 43(10), 800-814.
van, T. SJ., Jacobs, BC., Ooijevaar-de, H. P., Fokkink, WR., Huizinga, R., Vidarsson, G., & Rispens, T. (2022). Novel approach to monitor intravenous immunoglobulin pharmacokinetics in humans using polymorphic determinants in IgG1 constant domains. European Journal of Immunology, 609-617.
Brinkhaus, M., van, D. K. EJ., Bentlage, AEH., Ooijevaar-de, H. P., Derksen, NIL., Rispens, T., & Vidarsson, G. (2022). Human IgE does not bind to human FcRn. Scientific Reports, 12(1), [62].
Pongracz, T., Nouta, J., Wang, W., van, M. KE., Linty, F., Vidarsson, G., Joosten, SA., Ottenhoff, THM., Hokke, CH., de, V. JJC., Arbous, SM., Roukens, AHE., & groups, COVID. (2022). Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19. EBioMedicine, 78(April 01), [103957].
Van Osch, TLJ., Oosterhoff, JJ., Bentlage, AEH., Nouta, J., Koeleman, CAM., Geerdes, DM., Mok, JY., Heidt, S., Mulder, A., Van, E. WJE., Kapur, R., Porcelijn, L., & Vidarsson, G. (2022). Fc galactosylation of anti-platelet human IgG1 alloantibodies enhances complement activation on platelets. Haematologica, 107(10), 2432-2444.
M酶rtberg, T. V., Zhi, H., Vidarsson, G., Foss, S., Lissenberg-Thunnissen, S., Wuhrer, M., Michaelsen, T. E., Skogen, B., Stuge, T. B., Andersen, J. T., Newman, P. J., & Ahlen, M. T. (2022). Prevention of Fetal/Neonatal Alloimmune Thrombocytopenia in Mice: Biochemical and Cell Biological Characterization of Isoforms of a Human Monoclonal Antibody. ImmunoHorizons, 6(1), 99-103.
Rees, D. J. V., Brinkhaus, M., Klein, B., Verkuijlen, P., Tool, A. T. J., Schornagel, K., Treffers, L. W., Houdt, M. V., Kater, A. P., Vidarsson, G., Gennery, A. R., Kuijpers, T. W., Bruggen, R. V., Matlung, H. L., & Berg, T. K. V. D. (2022). Sodium stibogluconate and CD47-SIRPa blockade overcome resistance of anti-CD20鈥搊psonized B cells to neutrophil killing. Blood advances, 6(7), 2156鈥�2166.
Hviid, L., Lopez-Perez, M., Larsen, M. D., & Vidarsson, G. (2022). No sweet deal: the antibody-mediated immune response to malaria. Trends in Parasitology, 38(6), 428-434.
Pongracz, T., Vidarsson, G., & Wuhrer, M. (2022). Antibody glycosylation in COVID-19. Glycoconjugate Journal, 39(3), 335鈥�344.
2021
Scholarly publications
Norris, P. A. A., Segel, G. B., Burack, W. R., Sachs, U. J., Lissenberg-Thunnissen, S. N., Vidarsson, G., Bayat, B., Cserti-Gazdewich, C. M., Callum, J., Lin, Y., Branch, D., Kapur, R., Semple, J. W., & Lazarus, A. H. (2021). Fc纬RI and Fc纬RIII on splenic macrophages mediate phagocytosis of anti-glycoprotein IIb/IIIa autoantibody-opsonized platelets in immune thrombocytopenia. Haematologica, 106(1), 250-254.
Schmidt, D. E., Wendtland Edslev, P., Heitink-Poll茅, K. M. J., Mertens, B., Bruin, M. C. A., Kapur, R., Vidarsson, G., van der Schoot, C. E., Porcelijn, L., van der Bom, J. G., Rosth酶j, S., & de Haas, M. (2021). A clinical prediction score for transient versus persistent childhood immune thrombocytopenia. Journal of Thrombosis and Haemostasis, 19(1), 121-130.
Heemskerk, N., Gruijs, M., Robin Temming, A., Heineke, M. H., Gout, D. Y., Hellingman, T., Tuk, C. W., Winter, P. J., Lissenberg-Thunnissen, S., Bentlage, A. E. H., De Donatis, M., B枚gels, M., R枚sner, T., Valerius, T., Bakema, J. E., Vidarsson, G., & Van Egmond, M. (2021). Augmented antibody-based anticancer therapeutics boost neutrophil cytotoxicity. Journal of Clinical Investigation, 131(6), 1-16. [e134680].
Temming, AR., Tammes, B. M., Bentlage, AEH., Treffers, LW., Feringa, H., de, T. SW., Kuijpers, TW., Nagelkerke, SQ., Brasser, G., Mok, JY., van, E. WJE., & Vidarsson, G. (2021). C-Reactive Protein Enhances IgG-Mediated Cellular Destruction Through IgG-Fc Receptors in vitro. Frontiers in Immunology, 12, 1-17. [594773].
Crowley, A., Osei-Owusu, N., Dekkers, G., Gao, W., Wuhrer, M., Magnani, D., Reimann, K., Pincus, S., Vidarsson, G., & Ackerman, M. (2021). Biophysical Evaluation of Rhesus Macaque Fc Gamma Receptors Reveals Similar IgG Fc Glycoform Preferences to Human Receptors. Frontiers in Immunology.
Lippold, S., Knaupp, A., Ru, A. H. D., Tjokrodirijo, R. T. N., Veelen, P. A. V., Puijenbroek, E. V., Taeye, S. W. D., Reusch, D., Vidarsson, G., Wuhrer, M., Schlothauer, T., & Falck, D. (2021). Fc gamma receptor IIIb binding of individual antibody proteoforms resolved by affinity chromatography鈥搈ass spectrometry. mAbs, 13(1), [1982847 ].
Schmidt, D. E., Heitink鈥怭oll茅, K. M. J., Mertens, B., Porcelijn, L., Kapur, R., Schoot, C. E., Vidarsson, G., Bom, J. G., Bruin, M. C. A., & Haas, M. (2021). Biological stratification of clinical disease courses in childhood immune thrombocytopenia. Journal of Thrombosis and Haemostasis, 19(4), 1071-1081.
Vos, T. W. D., Winkelhorst, D., Baelde, H. J., Dijkstra, K. L., Bergen, R. D. M. V., Meeren, L. E. V. D., Nikkels, P. G. J., Porcelijn, L., Schoot, C. E. V. D., Vidarsson, G., Eikmans, M., Kapur, R., Keur, C. V. D., Trouw, L. A., Oepkes, D., Lopriore, E., Hoorn, M-L. P. V. D., Bos, M., & Haas, M. D. (2021). Placental Complement Activation in Fetal and Neonatal Alloimmune Thrombocytopenia: An Observational Study. International Journal of Molecular Sciences, 22(13), 1-11. [6763].
Braster, R., B枚gels, M., Benonisson, H., Wuhrer, M., Plomp, R., Bentlage, A., Korthouwer, R., Visser, R., Verbeek, J. S., Egmond, M. V., & Vidarsson, G. (2021). Afucosylated IgG Targets Fc纬RIV for Enhanced Tumor Therapy in Mice. Cancers, 13(10), [2372].
Jolink, A-T. C., Nelson, V. S., Schipperus, M. R., Amini, S. N., Vidarsson, G., Schoot, C. E. V. D., Porcelijn, L., Haas, M. D., & Kapur, R. (2021). Potential Diagnostic Approaches for Prediction of Therapeutic Responses in Immune Thrombocytopenia. Journal of Clinical Medicine, 10(15), 1-15. [3403].
Spanov, B., Olaleye, O., Lingg, N., Bentlage, AEH., Govorukhina, N., Hermans, J., van, D. M. N., Vidarsson, G., Jungbauer, A., & Bischoff, R. (2021). Change of charge variant composition of trastuzumab upon stressing at physiological conditions. Journal of chromatography. A, 1655, [462506].
Zillikens, H., Kasprick, A., Osterloh, C., Gross, N., Radziewitz, M., Hass, C., Hartmann, V., Behnen-H盲rer, M., Ernst, N., Boch, K., Vidarsson, G., Visser, R., Laskay, T., & Bieber, K. (2021). Topical Application of the PI3K尾-Selective Small Molecule Inhibitor TGX-221 Is an Effective Treatment Option for Experimental Epidermolysis Bullosa Acquisita. Frontiers in Medicine, 8, 1-16. [713312].
Wolfe, GI., Ward, ES., de, H. H., Ulrichts, P., Mozaffar, T., Pasnoor, M., & Vidarsson, G. (2021). IgG regulation through FcRn blocking: A novel mechanism for the treatment of myasthenia gravis. Journal of the Neurological Sciences, 430, 1-10. [118074].
Osch, T. L. J. V., Nouta, J., Derksen, N. I. L., Mierlo, G. V., Schoot, C. E. V. D., Wuhrer, M., Rispens, T., & Vidarsson, G. (2021). Fc Galactosylation Promotes Hexamerization of Human IgG1, Leading to Enhanced Classical Complement Activation. Journal of Immunology, 207(6), 1545鈥�1554.
Larsen, MD., Lopez-Perez, M., Dickson, EK., Ampomah, P., Tuikue, N. N., Nouta, J., Koeleman, CAM., Ederveen, ALH., Mordm眉ller, B., Salanti, A., Nielsen, MA., & Vidarsson, G. (2021). Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination. Nature Communications, 12, 1-10. [5838].
Bye, A. P., Hoepel, W., Mitchell, J. L., J茅gouic, S., Loureiro, S., Sage, T., Vidarsson, G., Nouta, J., Wuhrer, M., Taeye, S. D., Gils, M. V., Kriek, N., Cooper, N., Jones, I., Dunnen, J. D., & Gibbins, J. M. (2021). Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a prothrombotic stimulus for platelets. Blood, 138(16), 1481鈥�1489.
Wojcik, I., Schmidt, DE., de, N. LA., Rab, MAE., Meek, B., de, W. O., Wuhrer, M., van, D. S. CE., Zwaginga, JJ., de, H. M., Falck, D., & Vidarsson, G. (2021). A functional spleen contributes to afucosylated IgG in humans. Scientific Reports, 11, 1-9. [24045 ].
2020
Scholarly publications
Shinde, P., Howie, H. L., Stegmann, T. C., Hay, A. M., Waterman, H. R., Szittner, Z., Bentlage, A. E. H., Kapp, L., Lissenberg-Thunnissen, S. N., Dekkers, G., Schasfoort, R. B. M., Ratcliffe, S. J., Smolkin, M. E., Vidarsson, G., van der Schoot, C. E., Hudson, K. E., & Zimring, J. C. (2020). IgG Subclass Determines Suppression Versus Enhancement of Humoral Alloimmunity to Kell RBC Antigens in Mice. Frontiers in Immunology, 11, 1516.
St眉ssel, P., Schulze Dieckhoff, K., K眉nzel, S., Hartmann, V., Gupta, Y., Kaiser, G., Veldkamp, W., Vidarsson, G., Visser, R., Ghorbanalipoor, S., Matsumoto, K., Krause, M., Petersen, F., Kalies, K., Ludwig, R. J., & Bieber, K. (2020). Propranolol Is an Effective Topical and Systemic Treatment Option for Experimental Epidermolysis Bullosa Acquisita. Journal of Investigative Dermatology, 140(12), 2408-2420.
Brouwer, P. J. M., Caniels, T. G., van der Straten, K., Snitselaar, J. L., Aldon, Y., Bangaru, S., Torres, J. L., Okba, N. M. A., Claireaux, M., Kerster, G., Bentlage, A. E. H., van Haaren, M. M., Guerra, D., Burger, J. A., Schermer, E. E., Verheul, K. D., van der Velde, N., van der Kooi, A., van Schooten, J., ... van Gils, M. J. (2020). Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability. Science (New York, N.Y.), 369(6504), 643-650.
de Taeye, S. W., Bentlage, A. E. H., Mebius, M. M., Meesters, J. I., Lissenberg-Thunnissen, S., Falck, D., S茅nard, T., Salehi, N., Wuhrer, M., Schuurman, J., Labrijn, A. F., Rispens, T., & Vidarsson, G. (2020). Fc纬R Binding and ADCC Activity of Human IgG Allotypes. Frontiers in Immunology, 11, 740.
Zeeuw van der Laan, E. A. N., van der Velden, S., Bentlage, A. E. H., Larsen, M. D., van Osch, T. L. J., Mok, J. Y., Brasser, G., Geerdes, D. M., Koeleman, C. A. M., Nouta, J., Semple, J. W., Porcelijn, L., van Esch, W. J. E., Wuhrer, M., van der Schoot, C. E., Vidarsson, G., & Kapur, R. (2020). Biological and structural characterization of murine TRALI antibody reveals increased Fc-mediated complement activation. Blood advances, 4(16), 3875-3885.
Wojcik, I., S茅nard, T., de Graaf, E. L., Janssen, G. M. C., de Ru, A. H., Mohammed, Y., van Veelen, P. A., Vidarsson, G., Wuhrer, M., & Falck, D. (2020). Site-Specific Glycosylation Mapping of Fc Gamma Receptor IIIb from Neutrophils of Individual Healthy Donors. Analytical Chemistry, 92(19), 13172-13181.
S茅nard, T., Gargano, A. F. G., Falck, D., de Taeye, S. W., Rispens, T., Vidarsson, G., Wuhrer, M., Somsen, G. W., & Dom铆nguez-Vega, E. (2020). MS-Based Allotype-Specific Analysis of Polyclonal IgG-Fc N-Glycosylation. Frontiers in Immunology, 11, 2049.
Oja, A. E., Saris, A., Ghandour, C. A., Kragten, N. A. M., Hogema, B. M., Nossent, E. J., Heunks, L. M. A., Cuvalay, S., Slot, E., Linty, F., Swaneveld, F. H., Vrielink, H., Vidarsson, G., Rispens, T., van der Schoot, E., van Lier, R. A. W., Ten Brinke, A., & Hombrink, P. (2020). Divergent SARS-CoV-2-specific T- and B-cell responses in severe but not mild COVID-19 patients. European Journal of Immunology, 50(12), 1998-2012.
Brinkhaus, M., Douwes, R. G. J., Bentlage, A. E. H., Temming, A. R., de Taeye, S. W., Tammes Buirs, M., Gerritsen, J., Mok, J. Y., Brasser, G., Ligthart, P. C., van Esch, W. J. E., Verheesen, P., de Haard, H., Rispens, T., & Vidarsson, G. (2020). Glycine 236 in the Lower Hinge Region of Human IgG1 Differentiates Fc纬R from Complement Effector Function. Journal of Immunology, 205(12), 3456-3467.
Hoepel, W., Allahverdiyeva, S., Harbiye, H., de Taeye, S. W., van der Ham, A. J., de Boer, L., Zaat, S. A. J., van Weeghel, M., Baeten, D. L. P., Houtkooper, R. H., Everts, B., Vidarsson, G., & den Dunnen, J. (2020). IgG Subclasses Shape Cytokine Responses by Human Myeloid Immune Cells through Differential Metabolic Reprogramming. Journal of Immunology, 205(12), 3400-3407.
Hoepel, W., Allahverdiyeva, S., Harbiye, H., de Taeye, S. W., van der Ham, A. J., de Boer, L., Zaat, S. A. J., van Weeghel, M., Baeten, D. L. P., Houtkooper, R. H., Everts, B., Vidarsson, G., & den Dunnen, J. (2020). IgG Subclasses Shape Cytokine Responses by Human Myeloid Immune Cells through Differential Metabolic Reprogramming. Journal of Immunology, 205(12), 3400-3407.
Larsen, MD., de, G. EL., Sonneveld, ME., Plomp, HR., Nouta, J., Hoepel, W., Chen, HJ., Linty, F., Visser, R., Brinkhaus, M., 艩u拧ti膰, T., de, T. SW., Bentlage, AEH., & Vidarsson, G. (2020). Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity. Science (New York, N.Y.).