"Working in the field of innovative medicines is a win-win situation"
Associate Professor of Computational Medicinal Chemistry at Utrecht 木瓜福利影视. Managing Director of the Utrecht Institute for Pharmaceutical Sciences. Member Departmental Executive Board. Chair of the Board of Examiners of the School of Pharmacy.
Remdesivir monophosphate is linked to the growing RNA chain by the RdRp enzyme from SARS-CoV2. Pyrophoshate is spliced off, on the right. Magenta Mg2+ ions. The long bonds are not real but depict secondary structure,
Comparison of endogenous peptide (Leu-enkephalin) with a plant alkaloid (morphine) and the smallest chemical structure with similar activity (pethidine).
Substrate folate (blue) in the active site of Dihydrofolate reductase (yellow), with cofactor NADPH below (magenta).
Docking, with Autodock, of a steroid to an antibody to predict the binding site.
Poster on IT in education
David de Wied studied neuropeptides like vasopressin (left) and oxytocin (right). These images were made based on experimental 3D structures and now decorate the cryo-EM facility in the David de Wied building.