"From Data to Structures"2004

Advanced Course

"From Data to Structures"
May 17-June 11 2004, Utrecht Nijmegen

 

The Bijvoet-NSR Research Alliance (BNRA) organizes from May 17th to June 11th 2004 a course dealing with the structure determination of proteins and DNA from nuclear magnetic resonance spectroscopy data.

The course is given partly in Utrecht and in Nijmegen. The course duration is two weeks split over a four weeks period. Participation is free for members of the groups of the Bijvoet-NSR Research Alliance. The registration fee for participants from other universities amounts to Euro 350.- and for others to Euro 1000.-. The number of participants is limited to 16.

Course contents 

The courses consists of lectures and practical sessions. Topics such as data processing and analysis and structure determination and validation of biomolecules will be discussed. The acquired knowledge will be directly applied in the practical sessions. During those, the structure of a small protein based on NMR data will be calculated using state-of-the-art protocols. The effect of the number and quality of the included experimental data on the quality of the generated structures will be investigated. The results will be presented the last day. 

Lecturers:

  • Prof. Dr. Rolf Boelens Utrecht 木瓜福利影视
  • Dr. Alexandre M.J.J. Bonvin Utrecht 木瓜福利影视
  • Dr. Martin Blackledge IBS Grenoble
  • Dr. Hans A. Heus 木瓜福利影视 of Nijmegen
  • Dr. Torsten Herrmann, ETH Zurich
  • Drs. Sander Nabuurs, CMBI Nijmegen
  • Dr. Chris A.E.M Spronk, CMBI Nijmegen
  • Dr. Marco Tessari, 木瓜福利影视 of Nijmegen
  • Dr. Geerten W. Vuister, 木瓜福利影视 of Nijmegen
  • Dr. Wim Vranken, EBI Hinxton


Language: English

Prerequisite knowledge: 

The course is intended for Ph.D. students and advanced undergraduate students who already have a thorough knowledge of NMR spectroscopy. Experience with NMR structure determination methods is strongly recommended.


Registration 

For registration contact the secretary of the

Bijvoet Center for Biomolecular Research
Padualaan 8, 3584 CH Utrecht
Phone: 030-2532652 Fax: 030-2537623
Email: secr@nmr.chem.uu.nl


The registration deadline in April 30. Applicants will receive an acceptance notice as soon as possible.

Course topics

  • Prof. Dr. R. Boelens: NOEs and data processing
  • Dr. A.M.J.J. Bonvin: Molecular dynamics, force fields, NMR structure calculation
  • Dr. M. Blackledge: Dipolar couplings and orientational restraints
  • Dr. H.A. Heus: Nucleic Acids
  • Dr. T. Herrmann: Automated NOE assignment & structure calculations
  • Dr. C.A.E.M. Spronk: Structure validation
  • Dr. M. Tessari: Relaxation and dynamics
  • Dr. G.W. Vuister: J-coupling and chemical shifts 

New tools:

  1. Dr. W. Vranken: CCPN collaborative computing project for NMR
  2. Dr. A.M.J.J. Bonvin: HADDOCK high ambiguity driven docking
  3. Drs. S. Nabuurs: QUEEN quantitative evaluation of experimental NMR restraints