Publications older than 2015

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Publications 2014

't Hart, P., Kleijn, L. H. J., de Bruin, G., Oppedijk, S. F., Kemmink, J. & Martin, N. I. A combined solid- and solution-phase approach provides convenient access to analogues of the calcium-dependent lipopeptide antibiotics. 14 Feb 2014 In : Organic & Biomolecular Chemistry. 12, 6, p. 913-8 6 p.
Rijkers, D. T. S. A conformationally constrained fused tricyclic pisin AB-ring system mimic toward an improved pyrophosphate binder of lipid II. 2014 In : Tetrahedron. 70, p. 7691-7699
Van Ameijde, J., Overvoorde, J., Knapp, S., Den Hertog, J., Ruijtenbeek, R. & Liskamp, R. M. A new way to interrogate PTPs. 1 Mar 2014 In : Assay and Drug Development Technologies. 12, 2, p. 105-106 2 p.
González-Ortiz, G., Bronsoms, S., Quarles Van Ufford, H. C., Halkes, S. B. A., Virkola, R., Liskamp, R. M. J., Beukelman, C. J., Pieters, R. J., Pérez, J. F. & Martín-Orúe, S. M. A proteinaceous fraction of wheat bran may interfere in the attachment of enterotoxigenic E. coli K88 (F4+) to porcine epithelial cells. 2014 In : PLoS One. 9, 8, p. e104258
van Ameijde, J., Overvoorde, J., Knapp, S., den Hertog, J., Ruijtenbeek, R. & Liskamp, R. M. J. A versatile spectrophotometric protein tyrosine phosphatase assay based on 3-nitrophosphotyrosine containing substrates. 2014 In : Analytical Biochemistry. 448, p. 9-13 5 p.
van Ameijde, J., Zwiebel, A. P. R., Ruijtenbeek, R. & Liskamp, R. M. J. Azide-alkyne cycloaddition affording enzymatically tunable bisubstrate based inhibitors of histone acetyltransferase PCAF. 1 Jan 2014 In : Bioorganic & Medicinal Chemistry Letters. 24, 1, p. 113-6 4 p.
Cleophas, R. T. C., Sjollema, J., Busscher, H. J., Kruijtzer, J. A. W. & Liskamp, R. M. J. Characterization and activity of an immobilized antimicrobial peptide containing bactericidal PEG-hydrogel. 8 Sep 2014 In : Biomacromolecules. 15, 9, p. 3390-5 6 p.
Koelink, P. J., Overbeek, S. A., Braber, S., Morgan, M. E., Henricks, P. A. J., Abdul Roda, M., Verspaget, H. W., Wolfkamp, S. C., te Velde, A. A., Jones, C. W., Jackson, P. L., Blalock, J. E., Sparidans, R. W., Kruijtzer, J. A. W., Garssen, J., Folkerts, G. & Kraneveld, A. D. Collagen degradation and neutrophilic infiltration: a vicious circle in inflammatory bowel disease 2014 In : Gut. 63, p. 578-587 10 p.
Wang, L., Cummings, R. D., Smith, D. F., Huflejt, M., Campbell, C. T., Gildersleeve, J. C., Gerlach, J. Q., Kilcoyne, M., Joshi, L., Serna, S., Reichardt, N-C., Parera Pera, N., Pieters, R. J., Eng, W. & Mahal, L. K. Cross-platform comparison of glycan microarray formatsJun 2014 In : Glycobiology. 24, 6, p. 507-17 11 p.
van de Langemheen, H., Quarles van Ufford, H. L. C., Kruijtzer, J. A. W. & Liskamp, R. M. J. Efficient synthesis of protein mimics by sequential native chemical ligation. 18 Apr 2014 In : Organic Letters. 16, 8, p. 2138-41 4 p.
de Vries, R. P., Zhu, X., McBride, R., Rigter, A., Hanson, A., Zhong, G., Hatta, M., Xu, R., Yu, W., Kawaoka, Y., de Haan, C. A. M., Wilson, I. A. & Paulson, J. C. Hemagglutinin receptor specificity and structural analyses of respiratory droplet-transmissible H5N1 virusesJan 2014 In : Journal of Virology. 88, 1, p. 768-73 6 p.
Mens, S. P. V. Interactions between Streptococcus pneumoniae and the human host. 4 Nov 2014 Utrecht: Utrecht ľ�ϸ��Ӱ��. 221 p.
Spoorenberg, S. M. C., Bos, W. J., Heijligenberg, R., Voorn, G. P., Grutters, J. C., Rijkers, G. T. & van de Garde, E. M. W. Microbial aetiology, outcomes, and costs of hospitalisation for community-aquired pneumonia; an observational analysis. 2014 In : BMC Infectious Diseases [E]. 14, p. 335 1 p.
González-Ortiz, G., Quarles Van Ufford, H. C., Halkes, S. B. A., Cerdà-Cuéllar, M., Beukelman, C. J., Pieters, R. J.M. Liskamp, R. M. J., Pérez, J. F. & Martín-Orue, S. M. New properties of wheat bran: anti-biofilm activity and interference with bacteria quorum-sensing systems2014 In : Environmental Microbiology. 16, 5, p. 1346-1353 8 p.
Mooney, C. A., Johnson, S. A., 'T Hart, P., Quarles Van Ufford, L., De Haan, C. A. M., Moret, E. E. & Martin, N. I. Oseltamivir analogues bearing N-substituted guanidines as potent neuraminidase inhibitors. 10 Apr 2014 In : Journal of Medicinal Chemistry. 57, 7, p. 3154-3160 7 p.
Liskamp, R. M. J. Peptides: Bicycling into cells 2014 In : Nature Chemistry. 6, 10, p. 855-7 3 p.
Spoorenberg, S. M. C., Deneer, V. H. M., Grutters, J. C., Pulles, A. E., Voorn, G. P., Rijkers, G. T., Bos, J. W. J. & van de Garde, E. M. W. Pharmacokinetics of oral vs. intravenous dexamethasone in patients hospitalized with community-aquired pneumonia 2014 In : British Journal of Clinical Pharmacology. 78, 1, p. 78-83 6 p.
Elgersma, R. C., Kroon - Batenburg, L., Posthuma, G., Meeldijk, J. D., Rijkers, D. T. S. & Liskamp, R. M. J. PH-controlled aggregation polymorphism of amyloidogenic Aβ (16-22): Insights for obtaining peptide tapes and peptide nanotubes, as function of the N -terminal capping moiety. 17 Dec 2014 In : European Journal of Medicinal Chemistry. 88, p. 55-65 11 p.
Thomas, D., Koopmans, T., Lakowski, T. M., Kreinin, H., Vhuiyan, M. I., Sedlock, S. A., Bui, J. M., Martin, N. I. & Frankel, A. Protein arginine N-methyltransferase substrate preferences for different nη-substituted arginyl peptides21 Jul 2014 In : ChemBioChem. 15, 11, p. 1607-13 7 p.
van de Langemheen, W. Protein mimics by attachment of cyclic peptides to molecular scaffolds. 18 Sep 2014 's-Hertogenbosch: Uitgeverij BOXPress. 215 p.
Verhage, R. J. J., Boone, J., Rijkers, G. T., Cromheecke, G. J., Kroese, A. C., Weijs, T. J., Borel Rinkes, I. H. M. & van Hillegersberg, R. Reduced local immune response with continuous positive airway pressure during one-lung ventilation for oesophagectomy.2014 In : British Journal of Anaesthesia. 112, 5, p. 920-928 9 p.
van de Langemheen, H., van Hoeke, M., Quarles van Ufford, H. C., Kruijtzer, J. A. W. & Liskamp, R. M. J. Scaffolded multiple cyclic peptide libraries for protein mimics by native chemical ligation. 7 Jul 2014 In : Organic & Biomolecular Chemistry. 12, 25, p. 4471-4478 8 p.
Dubiella, C., Cui, H., Gersch, M., Brouwer, A. J., Sieber, S. A., Krüger, A., Liskamp, R. M. J. & Groll, M. Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site. 2014 In :Angewandte Chemie-International Edition. 53, 44, p. 11969-11973 5 p.
Slootweg, J. C., Peters, N., Quarles Van Ufford, H. C., Breukink, E., Liskamp, R. M. J. & Rijkers, D. T. S. Semi-synthesis of biologically active nisin hybrids composed of the native lanthionine ABC-fragment and a cross-stapled synthetic DE-fragment. 1 Oct 2014 In : Bioorganic & Medicinal Chemistry. 22, 19, p. 5345-5353 9 p.
Van Vught, R., Pieters, R. J. & Breukink, E. Site-specific functionalization of proteins and their applications to therapeutic antibodies. 1 Jan 2014 In : Computational and Structural Biotechnology Journal. 9, 14, e201402001
Dekker, F. J., van den Bosch, T. & Martin, N. I. Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases. 2014 In : Drug Discovery Today. 19, 5, p. 654-60 7 p.
Mohammadi, T., Sijbrandi, R., Lutters, M., Verheul, J., Martin, N. I., den Blaauwen, T., de Kruijff, B. & Breukink, E. Specificity of the transport of lipid II by FtsW in Escherichia coli. 2014 In: Journal of Biological Chemistry. 289, 21, p. 14707-14718 12 p.
Hajmohammadebrahimtehrani, K., Mashayekhi, V., Azerang, P., Sardari, S., Kobarfard, F. & Rostamizadeh, K. Synthesis and Antimycobacterial Activity of Novel Thiadiazolylhydrazones of 1-Substituted Indole-3-carboxaldehydes. 2014 In : Chemical Biology & Drug Design. 83, 2, p. 224-236
Brouwer, A. J., van de Langemheen, H., Ciaffoni, A., Schilder, K. E. & Liskamp, R. M. J. Synthesis of the TACO scaffold as a new selectively deprotectable conformationally restricted triazacyclophane based scaffold. 6 Jun 2014 In : Organic Letters. 16, 11, p. 3106-3109 4 p.
Eskandariyan, Z., Esfahani Zadeh, M., Hajmohammadebrahimtehrani, K., Mashayekhi, V. & Kobarfard, F. Synthesis of thioether derivatives of quinazoline-4-one-2-thione and evaluation of their antiplatelet aggregation activity. 2014 In : Archives of Pharmacal Research. 37, 3, p. 332-339
Boere, K. W. M., Soliman, B. G., Rijkers, D. T. S., Hennink, W. E. & Vermonden, T. Thermoresponsive Injectable Hydrogels Cross-Linked by Native Chemical Ligation. 8 Apr 2014 In : Macromolecules. 47, 7, p. 2430-2438 9 p.
van der Wal, S. Towards Bio-inspired and Functionalized Peptide Materials. 22 Sep 2014 Utrecht ľ�ϸ��Ӱ��. 153 p.
Werkhoven, P. R., van de Langemheen, H., van der Wal, S., Kruijtzer, J. A. W. & Liskamp, R. M. J. Versatile convergent synthesis of a three peptide loop containing protein mimic of whooping cough pertactin by successive Cu(I)-catalyzed azide alkyne cycloaddition on an orthogonal alkyne functionalized TAC-scaffold. Apr 2014 In : Journal of Peptide Science. 20, 4, p. 235-9 5 p.
Kok, M. G. M. Capillary electrophoresis and hydrophilic interaction chromatography coupled to mass spectrometry for anionic metabolic profiling. 4 Jul 2014 Utrecht ľ�ϸ��Ӱ��. 189 p.
Haselberg, R., Oliveira, S., van der Meel, R., Somsen, G. W. & de Jong, G. J. Capillary electrophoresis-based assessment of nanobody affinity and purity 2014 In : Analytica Chimica Acta. 818, p. 1-6 6 p.
Ramautar, R., Somsen, G. W. & de Jong, G. J. Developments in coupled solid-phase extraction-capillary electrophoresis 2011-2013. Jan 2014 In : Electrophoresis. 35, 1, p. 128-37 10 p.
Medina-Casanellas, S., Tak, Y. H., Benavente, F., Sanz-Nebot, V., Sastre Toraño, J., Somsen, G. W. & de Jong, G. J. Evaluation of fritless solid-phase extraction coupled on-line with capillary electrophoresis-mass spectrometry for the analysis of opioid peptides in cerebrospinal fluid. 2014 In : Electrophoresis. 35, 20, p. 2996-3002 7 p.
van Angeren, J., Jansen, R. L. & Brinkkemper, S. Exploring the Relationship between Platform Strategy and Interfirm Network Structure: An Analysis of the Office365 Ecosystem. 2014 Proceedings of the International Conference on Software Business.
Kok, M. G. M., Swann, J. R., Wilson, I. D., Somsen, G. W. & de Jong, G. J. Hydrophilic interaction chromatography-mass spectrometry for anionic metabolic profiling of urine from antibiotic-treated rats. Apr 2014 In : Journal of Pharmaceutical and Biomedical Analysis. 92, p. 98-104 7 p.
Heukers, R., Altintas, I., Raghoenath, S., De Zan, E., Pepermans, R., Roovers, R. C., Haselberg, R., Hennink, W. E., Schiffelers, R. M., Kok, R. J. & Van Bergen en Henegouwen, P. M. P. Targeting hepatocyte growth factor receptor (Met) positive tumor cells using internalizing nanobody-decorated albumin nanoparticles. 1 Jan 2014 In : Biomaterials. 35, 1, p. 601-610 10 p.

Publications 2013

Dissertatie intern (I)

Hattum, H. van (2013, april 08). Selective inhibition and detection of cancer-linked galectins by carbohydrate derivatives and conjugates. UU Universiteit Utrecht (131 pag.) ( Utrecht ľ�ϸ��Ӱ��). Prom./coprom.: prof. dr. R.J. Pieters.
Mulder, G.E. (2013, juni 24). Design and synthesis of discontinuous protein binding site mimics of HIV gp120. UU Universiteit Utrecht (160 pag.) ( Utrecht ľ�ϸ��Ӱ��). Prom./coprom.: prof. dr. R.M.J. Liskamp & dr. ir. J.A.W. Kruijtzer.
Pertici, F. (2013, augustus 30). New rigid spacers for multivalency studies: strong inhibition of Pseudomonas aeruginosa lectin LecA. UU Universiteit Utrecht (143 pag.) ( Utrecht ľ�ϸ��Ӱ��). Prom./coprom.: prof. dr. R.J. Pieters.
Slootweg, J.C. (2013, december 16). Semi-synthesis of nisin-based peptide antibiotics. UU Universiteit Utrecht (170 pag.) ( Utrecht ľ�ϸ��Ӱ��). Prom./coprom.: prof. dr. R.M.J. Liskamp & dr. ir. D.T.S. Rijkers.

Wetenschappelijke publicatie refereed

Ameijde, J. van, Overvoorde, J., Knapp, S., Hertog, J. den, Ruijtenbeek, R. & Liskamp, R.M.J. (2013). Real-time monitoring of dephosphorylating activity of protein tyrosine phosphatases using microarrays with 3-nitro-phosphotyrosine containing substrates. ChemPlusChem, 78, 1349-1357.
Beringer, D.X., Fischer, M.J.E., Meeldijk, J.D., Donselaar, E.G. van, Mol, N.J. de & Kroon-Batenburg, L.M.J. (2013). Tissue-type plasminogen activator binds to Abeta and AIAPP amyloid fibrils with multiple domains. Amyloid - Journal of Protein Folding Disorders, 20, 113-121.
Bernardi, A., Jimenez-Barbero, J., Casnati, A., De Castro, C., Darbre, T., Fieschi, F., Finne, J., Funken, H., Jaeger, K.-J., Lahmann, M., Lindhorst, T.K., Marradi, M., Messner, P., Molinaro, A., Murphy, P.V., Nativi, C., Oscarson, S., Penades, S., Peri, F., Pieters, R.J., Renaudet, O., Reymond, J.-L., Richichi, B., Rojo, J., Sansone, F., Schaffer, C., Turnbull, W.B., Velasco-Torrijos, T., Vidal, S., Vincent, S., Wennekes, T., Zuilhof, H. & Imberty, A. (2013). Multivalent glycoconjugates as anti-pathogenic agents. Chemical Society reviews, 42, 4709-4727.
Hattum, H. van, Martin, N.I., Ruijtenbeek, R. & Pieters, R.J. (2013). Development of a microarray detection method for galectin cancer proteins based on ligand binding. Analytical Biochemistry, 99-104.
Hattum, H. van, Branderhorst, H.M., Moret, E.E., Nilsson, U.J., Leffler, H. & Pieters, R.J. (2013). Tuning the preference of thiodigalactoside- and lactosamine-based ligands to galectin-3 over galectin-1. Journal of Medicinal Chemistry, 56(3), 1350-1354.
Koelink, P.J., Overbeek, S.A., Braber, S, Morgan, M.E., Henricks, P.A.J., Abdul Roda, M., Verspaget, H.W., Wolfkamp, S.C., Velde, A.A. te, Jones, C.W., Jackson, P.L., Blalock, J.E., Sparidans, R.W., Kruijtzer, J.A.W., Garssen, J., Folkerts, G. & Kraneveld, A.D. (2013). Collagen degradation and neutrophilic infiltration: a vicious circle in inflammatory bowel disease. Gut.
Kooij, R., Branderhorst, H.M., Bonte, S., Wieclawska, S., Martin, N.I. & Pieters, R.J. (in press). Glycosidase inhibition by novel guanidinium and urea iminosugar derivatives. MedChemComm, 4, 387-393.
Koopmans, T., Haren, M.J., Quarles van Ufford, H.C., Beekman, J. & Martin, N.I. (2013). A concise preparation of the fluorescent amino acid L-(7-hydroxycoumarin-4-yl) ethylglycine and extension of its utility in solid phase peptide synthesis. Bioorganic & Medicinal Chemistry, 553-559.
Kouki, A., Pieters, R.J., Nilsson, U.J., Loimaranta, V., Finne, J. & Haataja, S. (2013). Bacterial adhesion of Streptococcus suis to host cells and its inhibition by carbohydrate ligands. onbekend CHEM, 19, 918-935.
Meijerman, I., Storm, G., Moret, E.E. & Koster, A.S. (2013). Development and student evaluation of an inquiry-based elective course on drug discovery and preclinical drug development. Currents in Pharmacy Teaching and Learning, 5, 14-22.
Mol, N.J. de, Kruijtzer, J.A.W., Moret, E.E., Broutin, I. & Liskamp, R.M.J. (2013). Unusual binding of Grb2 protein to a bivalent polyproline-ligand immobilized on a SPR sensor: intermolecular bivalent binding. Biochimica et Biophysica Acta, 1834(2), 524-535.
Mooiman, K.D., Maas-Bakker, R.F.M., Moret, E.E., Beijnen, J.H., Schellens, J.H.M. & Meijerman, I. (2013). Milk Thistle's Active Components Silybin and Isosilybin: Novel Inhibitors of PXR-Mediated CYP3A4 Induction. Drug Metabolism and Disposition, 41, 1494-1504.
Mulder, G.E., Quarles van Ufford, H.C., Ameijde, J. van, Brouwer, A.J., Kruijtzer, J.A.W. & Liskamp, R.M.J. (2013). Scaffold optimization in discontinuous epitope containing protein mimics of gp120 using smart librariers. Organic & Biomolecular Chemistry, 11, 2676-2684.
Nuijens, T., Schepers, A.H.M., Cusan, C., Kruijtzer, J.A.W., Rijkers, D.T.S., Liskamp, R.M.J. & Quaedflieg, P.J.L.M. (2013). Enzymatic fragment condensation of side chain-protected peptides using subtilisin A in anhydrous organic solvents: A general strategy for industrial peptide synthesis. Advanced synthesis & catalysis, 355, 287-293.
Pertici, F., Varga, N., Duijn, A. van, Rey Carrizo, M., Bernardi, A. & Pieters, R.J. (2013). Efficient synthesis of phenylene-ethynylene rods and their use as rigid spacers in divalent inhibitors. Beilstein Journal of Organic Chemistry, 9, 215-222.
Pertici, F., Mol, N.J. de, Kemmink, J. & Pieters, R.J. (2013). Optimizing bivalent inhibitors of Pseudomonas aeruginosa lectin LecA using a rigid spacer. Chemistry-A European Journal, 19, 16923-16927.
Pieters, R.J., Slotved, H.-C., Moller Mortensen, H., Arler, L., Finne, J., Haataja, S., Joosten, J.A.F., Branderhorst, H.M. & Krogfelt, K.A. (2013). Use of tetravalent galabiose for inhibition of Streptococcus suis serotype 2 infection in a mouse model. onbekend CHEM, 2, 702-718.
Slootweg, J.C., Schaik, T.B. van, Quarles van Ufford, H.C., Breukink, E.J., Liskamp, R.M.J. & Rijkers, D.T.S. (2013). Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative. Bioorganic & Medicinal Chemistry Letters, 23, 3749-3752.
Slootweg, J.C., Liskamp, R.M.J. & Rijkers, D.T.S. (2013). Scalable purification of the lantibiotic nisin and isolation of chemical/enzymatic cleavage fragments suitable for semi-synthesis. Journal of peptide science, 19, 692-699.
Slootweg, J.C., Kemmink, J., Liskamp, R.M.J. & Rijkers, D.T.S. (2013). Synthesis and structural characterization of individual diastereoisomers of a cross-stapled alkene-bridged nisin DE-ring mimic. Organic & Biomolecular Chemistry, 11, 7486-7496.
Slootweg, J.C., Wal, S. van der, Quarles van Ufford, H.C., Breukink, E.J., Liskamp, R.M.J. & Rijkers, D.T.S. (2013). Synthesis, antimicrobial activity, and membrane permeabilizing properties of C-terminally modified conjugates accessed by CuAAC. Bioconjugate Chemistry, 24, 2058-2066.
Spaan, A.N., Henry, T., Rooijen, W.J.M. van, Perret, M., Badiou, C., Aerts, P.C., Kemmink, J., Gosselaar - de Haas, C.J.C. de, Kessel, C.P.M. van, Vandenesch, F., Lina, G. & Strijp, J.A.G. van (2013). The staphylococcal toxin Panton-Valentine Leukocidin targets human C5a receptors. Cell Host & Microbe, 13(5), 584-594.
Thomsen, L.B., Linemann, T., Pondman, K.M., Lichota, J., Kim, K.S., Pieters, R.J., Visser, G.M. & Moos, T. (2013). Uptake and Transport of Superparamagnetic Iron Oxide Nanoparticles through Human Brain Capillary Endothelial Cells. ACS Chemical Biology, 19, 16923-16927.
Tschan, S., Brouwer, A.J., Werkhoven, P.R., Jonker, A.M., Wagner, L., Knittel, S., Aminake, M.N., Pradel, G., Joanny, F., Liskamp, R.M.J. & Mordmuller, B. (2013). Broad-spectrum antimalarial activity of peptido sulfonyl fluorides, a new class of proteasome inhibitors. Antimicrobial Agents and Chemotherapy, 57, 3576-3584.
Vosyka, O., Vinothkumar, K.R., Wolf, E.V., Brouwer, A.J., Liskamp, R.M.J. & Verhelst, S.H.L. (2013). Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay. Proceedings of the National Academy of Sciences of the United States of America, 110, 2472-2477.
Wammes, A.E.M., Fischer, M.J.E., Mol, N.J. de, Eldijk, M.B. van, Rutjes, F.P.J.T., Hest, J.C.M. van & Delft, F.L. van (2013). Site-specific peptide and protein immobilization on surface plasmon resonance chips. Lab on a Chip Journal, 13, 1863-1867.
Wandelen, L.T.M. van, Ameijde, J. van, Ismail-Ali, A.F., Quarles van Ufford, H.C., Vijftigschild, L.A.W., Beekman, J.M., Martin, N.I., Ruijtenbeek, R. & Liskamp, R.M.J. (2013). Cell-penetrating bisubstrate-based protein kinase C inhibitors. ACS Chemical Biology, 8, 1479-1487.
Weijn, A., Berg-Somhorst, D.B. van den, Slootweg, J.C., Vincken, J.P., Gruppen, H, Wichers, H.J. & Mes, J.J. (2013). Main phenolic compounds of the melanin biosynthesis pathway in bruising-tolerant and bruising-sensitive button mushroom (Agaricus bisporus) strains. Journal of Agricultural and Food Chemistry, 61, 8224-8231.
Werkhoven, P.R. & Liskamp, R.M.J. (2013). Chemical approaches for localization, characterization and mimicry of peptide epitopes. In L.H. Jones & A.J. McKnight (Eds.), RSC Drug Discovery Series (pp. 263-284).
Wienk, H., Slootweg, J.C., Speerstra, S., Kaptein, R., Boelens, R. & Folkers, G.E. (2013). Solution structure of the helix hairpin helix domain of FAAP24 reveals that substrate specificity depends on an evolutionary conserved domain. Nucleic Acids Research, 41, 6739-6749.
Wittmann, V. & Pieters, R.J. (2013). Bridging lecting binding sites by my multivalent carbohydrates. Chemical Society reviews, 42, 4492-4503.
Zhang, J., Kemmink, J., Rijkers, D.T.S. & Liskamp, R.M.J. (2013). Synthesis of 1,5-triazole-bridged vancomycin CDE-ring bicyclic mimics using RuAAC macrocyclization. Chemical Communications, 49, 4498-4500.
Angeren, J. van, Kabbedijk, J., Popp, K.M. & Jansen, R.L. (2013). Managing Software Ecosystems through Partnering. In Software Ecosystems: Analyzing and Managing Business Networks in the Software Industry (pp. 85-102). Cheltenham, UK: Edward Elgar Publishing.
Haselberg, R., Jong, G.J. de & Somsen, G.W. (2013). CE-MS for the analysis of intact proteins 2010-2012. Electrophoresis, 34, 99-112.
Haselberg, R., Jong, G.J. de & Somsen, G.W. (2013). Low-flow sheathless capillary electrophoresis-mass spectrometry for sensitive glycoform profiling of intact pharmaceutical proteins. Analytical Chemistry, 85, 2289-2296.
Haselberg, R., Flesch, F.M., Boerke, A. & Somsen, G.W. (2013). Thickness and morphology of polyelectrolyte coatings on silica surfaces before and after protein exposure studied by atomic force microscopy. Analytica Chimica Acta, 779, 90-95.
Kok, M.G.M., Somsen, G.W. & Jong, G.J. de (2013). Anionic metabolic profiling of urine from antibiotic-treated rats by capillary electrophoresis-mass spectrometry. Analytical and Bioanalytical Chemistry, 405, 2585-2594.
Kort, B.J. de, Jong, G.J. de & Somsen, G.W. (2013). Native fluorescence detection of biomolecular and pharmaceutical compounds in capillary electrophoresis: detector designs, performance and applications: A review. Analytica Chimica Acta, 766, 13-33.
Kort, B.J. de, Jong, G.J. de & Somsen, G.W. (2013). Potential of capillary electrophoresis with wavelength-resolved fluorescence detection for protein unfolding studies using beta-lactoglobulin B as a test compound. Analyst, 138, 4550-4557.
Moreno-Gonzalez, D., Sastre Torano, J., Gamiz-Gracia, L., Garcia-Campana, A.M., Jong, G.J. de & Somsen, G.W. (2013). Micellar electrokinetic chromatography-electrospray ionization mass spectrometry employing a volatile surfactant for the analysis of amino acids in human urine. Electrophoresis, 34, 2615-2622.
Nunes, C., Schluepmann, H., Delatte, T.L., Wingler, A., Silva, A.B., Fevereiro, P.S., Jansen, M., Florani, F., Wiese-Klinkenberg, A. & Paul, M.J. (2013). Regulation of growth by the trehalose pathway: relationship to temperature and sucrose. Plant Signaling & Behavior.
Nunes, C., O'Hara, L.E., Primavesi, L.F., Delatte, T.L., Schluepmann, H., Somsen, G.W., Silva, A.B., Fevereiro, P.S., Wingler, A. & Paul, M.J. (2013). The trehalose 6-phosphate/SnRK1 signaling pathway primes growth recovery following relief of sink limitation. Plant physiology, 162, 1720-1732.
Ramautar, R. & Somsen, G.W. (2013). CE-MS or metabolomics: developments and applications in the period 2010-2012. Electrophoresis, 34, 86-98.
Ramautar, R., Somsen, G.W. & Jong, G.J. de (2013). The role of CE-MS in metabolomics. In M. Lammerhofer & W. Weckwerth (Eds.), Metabolomics in practice (pp. 177-206). Weinheim: Wiley-VCH.
Rozenbrand, J. & Bennekom, W.P. van (2013). Comments on the implementation of a simple peak capacity optimization procedure and comparison of poly(styrene-divinylbenzene) and RP-18 silica monolithic capillary columns of 5-cm for the analysis of protein digests. Chromatographia, 1595-1602.
Stigter, E.C.A., Jong, G.J. de & Bennekom, W.P. van (2013). Coupling surface-plasmon resonance and mass spectrometry to quantify and to identify ligands. onbekend CHEM, 74, 107-120.
Wijk, A.M. van, Niederlander, H.A.G., Siebum, A.H.G., Vervaart, M.A.T. & Jong, G.J. de (2013). A new derivatization reagent for LC-MS/MS screening of potential genotoxic alkylation compounds. Journal of Pharmaceutical and Biomedical Analysis, 74, 133-140.

Overig producten van wetenschappelijke activiteiten/lezingen

Dominguez Vega, E. (2013, maart 10). Compositional and site-specific characterization of peptide drug degradation by CE-MS/MS. Charlottesville, Congress.
Haselberg, R. (2013, april 26). CE-based assessment of nanbody affinity and purity. Breda, Joint KNCV/KVCV CE users meeting 2013.
Haselberg, R. (2013, oktober 09). CE-based assessment of nanobody affinity and purity. Arlington, CE Pharm 2013.
Haselberg, R. (2013, juni 09). Low-flow sheathless capillary electrophoresis-mass spectrometry for sensitive high-resolution glycoform profiling of intact pharmaceutical proteins. Minneapolis, ASMS2013.

Publications 2012

Albada, H.B., Soulimani, F., Jacobs, H.J.F., Versluis, C., Weckhuysen, B.M. & Liskamp, R.M.J.. Triazacyclophane (TAC)-scaffolded histidine and aspartic acid residues as mimics of non-heme metalloenzyme active sites. Organic & Biomolecular Chemistry, 2012, 10(5), 1088-10921.
Arnusch, C.J., Pieters, R.J. & Breukink, E.J.. Enhanced membrane pore formation through high-affinity targeted antimicrobial peptides. PLoS ONE [E], 2012, 7, e39768.
Arnusch, C.J., Albada, A., Vaardegem, M. van, Liskamp, R.M.J., Sahl, H.-G., Shadkchan, Y., Osherov, N. & Shai, Y.. Trivalent ultrashort lipopeptides are potent pH dependent antifungal agents. Journal of Medicinal Chemistry, 2012, 55, 1296-1302.
Chamorro Perez, M.C., Boerman, M.A., Arnusch, C.J., Breukink, E.J. & Pieters, R.J.. Enhancing membrane disruption by targeting and multivalent presentation of antimicrobial peptides. Biochimica et Biophysica Acta-Biomembranes, 2012, 1818, 2171-2174.
Crielaard, B.J., Rijcken, C.J.F., Quan, L., Wal, S. van der, Altintas, I., Pot, M. van der, Kruijtzer, J.A.W., Liskamp, R.M.J., Schiffelers, R.M., Nostrum, C.F. van, Hennink, W.E., Wang, D., Lammers, T.G.G.M. & Storm, G.. Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. Angewandte Chemie-International Edition, 2012, 29, 7254-7258.
Goermer, K., Buerger, M., Kruijtzer, J.A.W., Vetter, I., Vartak, N., Brunsveld, L., Bastiaens, P.I.H., Liskamp, R.M.J., Triola, G. & Waldmann, H.. Chemical-biological exploration of the limits of the ras de- and repalmitoylating machinery. ChemBioChem, 2012, 13, 1017-1023.
Graaf, A.J. de, Azevedo Próspero dos Santos, I.I., Pieters, E.H.E., Rijkers, D.T.S., Nostrum, C.F. van, Vermonden, T., Kok, R.J., Hennink, W.E. & Mastrobattista, E.. A micelle-shedding thermosensitive hydrogel as sustained release formulation. Journal of Controlled Release, 2012, 162, 582-590.
Graaf, A.J. de, Mastrobattista, E., Vermonden, T., Nostrum, C.F. van, Rijkers, D.T.S., Liskamp, R.M.J. & Hennink, W.E.. Thermosensitive peptide-hybrid ABC block copolymers obtained by ATRP: synthesis, self assembly, and enzymatic degradation. Macromolecules, 2012, 45, 842-851.
Halkes, S.B.A.. Cardiovasculaire effecten van duizendblad (Achillea millefolium L.). Nederlands tijdschrift voor fytotherapie, 2012, 3, 8-9.
Hart, P. 't, Thomas, D., Ommeren, R. van, Lakowski, T.M., Frankel, A. & Martin, N.I.. Analogues of the HIV-Tat peptide containing NNg-modified arginines as potent inhibitors of protein arginine N-methyltransferases. MedChemComm, 2012, 3, 1235-1244.
Hattum, H. van, Zwaluw, K. van der, Visser, G.M., Putten, J. van, Ruijtenbeek, R. & Pieters, R.J.. Functional assay for Shiga-like toxin via detection by antibody capture and multivalent galabiose binding. Bioorganic & Medicinal Chemistry Letters, 2012, 22, 7448-7450.
Kaaden, M. van der, Breukink, E.J. & Pieters, R.J.. Synthesis and antifungal properties of papulacandin derivatives. Beilstein Journal of Organic Chemistry, 2012, 8, 732-737.
Kleijn, L.H.J., Müskens, F.M., Oppedijk, S.F., Bruin, G. de & Martin, N.I.. A concise preparation of the non-proteinogenic amino acid L-kynurenine. Tetrahedron Letters, 2012, 53, 6430-6432.
Koopmans, T., Dekker, F.J. & Martin, N.I.. A photocleavable affinity tag for the enrichment of alkyne-modified biomolecules. RSC Advances, 2012, 2, 2244-2246.
Langemheen, W. van de, Brouwer, A.J., Kemmink, J., Kruijtzer, J.A.W. & Liskamp, R.M.J.. Synthesis of cyclic peptides containing a thioester handle for native chemical ligation. Journal of Organic Chemistry, 2012, 77, 10058-10064.
Mol, N.J. de. Surface plasmon resonance for proteomics. Methods in molecular biology, 2012, 800, 33-53.
Mulder, G.E., Kruijtzer, J.A.W. & Liskamp, R.M.J.. A combinatorial approach torward smart libraries of discontinuous epitopes of HIV gp 120 on a TAC synthetic scaffold. Chemical Communications, 2012, 48, 10007-10009.
Mulder, M.P.C., Fodran, P., Kemmink, J., Breukink, E.J., Kruijtzer, J.A.W., Minnaard, A.J. & Liskamp, R.M.J.. Mutual influence of backbone proline substitution and lipopholic tail character on the biological activity of simplified analogues of caspofungin. Organic & Biomolecular Chemistry, 2012, 10, 7491-7502.
Nuijens, T., Piva, E., Kruijtzer, J.A.W., Rijkers, D.T.S., Liskamp, R.M.J. & Quaedflieg, P.J.L.M.. Enzymatic C-terminal amidation of amino acids and peptides. Tetrahedron Letters, 2012, 53, 3777-3779.
Pertici, F. & Pieters, R.J.. Potent divalent inhibitors with rigid glucose click spacers for Pseudomonas aeruginosa lectin LecA. Chemical Communications, 2012, 48, 4008-4010.
Shinde, S., Bunschoten, A., Kruijtzer, J.A.W., Liskamp, R.M.J. & Sellergen, B.. Imprinted polymers displaying high affinity for sulfated protein fragments. Angewandte Chemie-International Edition, 2012, 51, 8326-8329.
Tazelaar, C.G.J., Lyaskovskyy, V., Dijk, T. van, Broere, D.L.J., Kolfschoten, L.A., Khiar, R.O.H., Lutz, M., Slootweg, J.C. & Lammertsma, K.. Tris(pyrazolyl)phosphine Oxides. Synthesis and Coordination Chemistry with Copper(I). Organometallics, 2012, 31(8), 3308-3315.
Thio, M., Groot Kormelink, T., Fischer, M.J.E., Blokhuis, B.R.J., Nijkamp, F.P. & Redegeld, F.A.M.. Antigen binding characteristics of immunoglobulin free light chains: crosslinking by antigen is essential to induce allergic inflammation. PLoS ONE [E], 2012, 7, 1-7.
Wandelen, L.T.M. van, Ameijde, J. van, Mady, A.S.A., Wammes, A.E.M., Bode, A., Poot, A.J., Ruijtenbeek, R. & Liskamp, R.M.J.. Directed modulation of protein kinase C isozyme selectivity with bisubstrate-based inhibitors. ChemMedChem, 2012, 7, 2113-2121.
Weymiens, W., Hartl, F., Lutz, M., Slootweg, J.C., Ehlers, A.W., Mulder, J.R. & Lammertsma, K.. Bis(azidophenyl)phosphole building block for extended π-conjugated systems. European Journal of Organic Chemistry, 2012(34), 6711-6721.

Congresbijdrage

Al Temimi, A., Liskamp, R.M.J. & Rijkers, D.T.S. (). Ring-closing metathesis and "click" cyclization of astressin-derived peptides as novel corticotropin releasing factor antagonists. In Program and Abstracts from the 32nd European Peptide Symposium Vol. 18. Journal of peptide science (pp. 184-185).

Cleophas, T.C., Riool, M., Zaat, S.A.J., Quaedflieg, P.J.L.M., Kruijtzer, J.A.W. & Liskamp, R.M.J. (2012). Stabilized antimicrobial peptide coatings. In 244th ACS National Meeting & Exposition. Kramer, N., Liskamp, R.M.J. & Rijkers, D.T.S. (). A convenient [2+2]cycloaddition-cycloreversion reaction for the synthesis of colourful peptides as new imaging chromophores. In Program and Abstracts from the 32nd European Peptide Symposium Vol. 18. Journal of peptide science (pp. 175).

Slootweg, J.C., Rijkers, D.T.S. & Liskamp, R.M.J.. Synthesis, structural characterization and application of crossed alkene-bridged nisin DE-ring mimics for semi-synthesis of nisin hybrid mimics. In Program and Abstracts from the 32nd European Peptide Symposium Vol. 18. Journal of peptide science (pp. 127-128).

Zhang, J., Longin, O., Rijkers, D.T.S. & Liskamp, R.M.J. (). Cu-(I)- and Ru(II)-catalyzed "click" macrocyclization of tripeptides: toward vancomycin-inspired mimics. In Program and Abstracts from the 32nd European Peptide Symposium Vol. 18. Journal of peptide science (pp. 118).

Zhang, J., Rijkers, D.T.S. & Liskamp, R.M.J.. Synthesis of bicyclic 1,5-triazole-bridged vancomycin CDE-ring peptidomimetics via RuAAC macrocyclization. In Program and Abstracts from the 32nd European Peptide Symposium Vol. 18. Journal of peptide science (pp. 24).

Ph.D. Thesis

Mulder, M.P.C. (2012, november 09).
Design, Synthesis and Evaluation of Macrocyclic Antifungal Peptides.
UU Universiteit Utrecht (163 pag.) ( Utrecht ľ�ϸ��Ӱ��).
Prom./coprom.: prof. dr. R.M.J. Liskamp & dr. ir. J.A.W. Kruijtzer.

Nuijens, T. (2012, mei 07).
Chemo-enzymatic peptide synthesis and derivatisation using Subtilisin A in anhydrous organic solvents.
UU Universiteit Utrecht (196 pag.) (Utrecht: Utrecht ľ�ϸ��Ӱ��).
Prom./coprom.: prof. dr. R.M.J. Liskamp, P.J.L.M. Quaedflieg & dr. ir. D.T.S. Rijkers.

Zhang, J. (2012, november 26).
Synthesis of Triazole Bridged Vancomycin Mimics.
UU Universiteit Utrecht (150 pag.) ( Utrecht ľ�ϸ��Ӱ��).
Prom./coprom.: prof. dr. R.M.J. Liskamp & dr. ir. D.T.S. Rijkers.

Octrooi

Pieters, R.J., Martin, N.I., Branderhorst, H.M. & Kooij, R. (2012) Urea and guanidinium derivates of iminosugars, 2009246, 27 Jul 2012.
Pieters, R.J., Martin, N.I., Branderhorst, H.M. & Kooij, R. (2012) Urea and guanidinium derivatives of iminosugars, 2009247, 27 Jul 2012.
Pieters, R.J., Martin, N.I., Branderhorst, H.M. & Kooij, R. (2012) Urea and guanidinium derivatives of iminosugars, 2009248, 27 Jul 2012.
Rijcken, C.J.F., Kruijtzer, J.A.W., Nostrum, C.F. van, Wal, S. van der, Hennink, W.E., Liskamp, R.M.J. & Altintas, I. (2012) Tunable, biodegradable linker molecules for transient conjugation of components in drug delivery systems, and drug delivery systems prepared therewith, WO 2012039602 A1, 29 Mar 2012.

Lezing

Mol, N.J. de (2012, juli 03). Moleculaire schakelaars: thermodynamica en kinetiek van eiwit-ligand interacties. Nijmegen, Eerste jaarssymposium Cluster Moleculaire Wetenschappen Radbout Universiteit Nijmegen.

Publications 2011

Briel, R. van de, Cransveld, C.C., Crommelin, D.J.A., Diamant, Z., Glazenburg, B., Joos, G., Kuper, F., Natsch, A., Nijkamp, F.P., Noteborn, H., Pieters, R.J., Roberts, D., Roggen, E., Rorije, E., Heuvel, R. van den, Engelen, J., Verstaelen, S. & Loveren, H. van. Respiratory sensitization: Advances in assessing the risk of respiratory inflammation and irritation. Toxicology in Vitro / 2011 / 25 / 1251-1258.
Brouwer, A.J. & Liskamp, R.M.J.A simple large-scale synthesis of Cbz-protected taurylsulfonyl azide. Synlett / 2011 / 15 / 2228-2230.
Brouwer, A.J., Ceylan, T., Jonker, A.M., Linden, T. van der & Liskamp, R.M.J. Synthesis and biological evaluation of novel irreversible serine protease inhibitors using amino acid based sulfonyl fluorides as an electrophilic trap. Bioorganic & Medicinal Chemistry/ 2011 / 19 / 2397-2406.
Bunschoten, A., Ippel, J.H., Kruijtzer, J.A.W., Feitsma, L.J., Haas, C.J.C. de, Liskamp, R.M.J. & Kemmink, J. A peptide mimic of the chemotaxis inhibitory protein of Staphylococcus aureus: towards the development of novel anti-inflammatory compounds. Amino acids / 2011 / 40 / 731-740.
Graaf, A.J. de, Mastrobattista, E., Nostrum, C.F. van, Rijkers, D.T.S., Hennink, W.E. & Vermonden, T. ATRP, subsequent azide substitution and "click" chemistry: three reactions using one catalyst in a one-pot. Chemical Communications / 2011 / 47 / 6972-6974.
Graaf, A.J. de, Boere, K.W.M., Kemmink, J., Fokkink, R.G., Nostrum, C.F. van, Rijkers, D.T.S., Gucht, J. van de, Wienk, H.L.J., Baldus, M., Mastrobattista, E., Vermonden, T. & Hennink, W.E. Looped structure of flowerlike Micelles revealed by 1H NMR relaxometry and light scattering. Langmuir / 2011 / 27(16) / 9843-9848.
Halkes, S.B.A., Beukelman, C.J., Vrolijk, R. & Berg, A.J.J. van den Honing voor de lokale behandeling van paarden met mok. Nederlands tijdschrift voor fytotherapie / 2011 / 4 / 13-16.
Hart, P. 't, Lakowski, T.M., Thomas, D., Frankel, A. & Martin, N.I. Peptidic partial-bisubstrates as inhibitors of the protein arginine N-methyltransferases. ChemBioChem / 2011 / 12 / 1427-1432.
Kuil, J., Fischer, M.J.E., Mol, N.J. de & Liskamp, R.M.J. Cell permeable ITAM constructs for the modulation of mediator release in mast cells. Organic & Biomolecular Chemistry / 2011 / 9 / 820-833.
Liskamp, R.M.J., Rijkers, D.T.S., Kruijtzer, J.A.W. & Kemmink, J. Peptides and proteins as a continuing exciting source of inspiration for peptidomimetics. ChemBioChem / 2011 / 12 / 1626-1653.
Lyaskovskyy, V., Elders, N., Ehlers, A.W., Lutz, M., Slootweg, J.C. & Lammertsma, K. Remarkable metal-complexed phosphorus analogues of the cyclopropenylcarbene–cyclobutadiene rearrangement. Journal of the American Chemical Society / 2011 / 133(25) / 9704-9707.
Mulder, M.P.C., Kruijtzer, J.A.W., Breukink, E.J., Kemmink, J., Pieters, R.J. & Liskamp, R.M.J. Synthesis and evaluation of novel macrocyclic antifungal peptides. Bioorganic & Medicinal Chemistry / 2011 / 19 / 6505-6517.
Nuijens, T., Cusan, C., Scheepers, A.C.H.M., Kruijtzer, J.A.W., Rijkers, D.T.S., Liskamp, R.M.J. & Quaedflieg, P.J.L.M. Enzymatic synthesis of activated esters and their subsequent use in enzyme-based peptide synthesis. Journal of Molecular Catalysis B-Enzymatic / 2011 / 71 / 79-84.
Nuijens, T., Piva, E., Kruijtzer, J.A.W., Rijkers, D.T.S., Liskamp, R.M.J. & Quaedflieg, P.J.L.M. Fully enzymatic N→C-directed peptide synthesis using C-terminal peptide α-carboxamide to ester interconversion. Advanced synthesis & catalysis / 2011 / 353 / 1039-1044.
Nyholm, T.K.M., Duyl, B.Y. van, Rijkers, D.T.S., Liskamp, R.M.J. & Killian, J.A. Probing the lipid-protein interface using model transmembrane peptides with a covalently linked acyl chain. Biophysical Journal / 2011 / 101 / 1959-1967.
Olrichs, N.K., Aarsman, M.E.G., Verheul, J,, Arnusch, C.J., Martin, N.I., Herve, M., Vollmer, W., Kruijff, B. de, Breukink, E.J. & Blaauwen, T.A. den A novel in vivo cell-wall labelling approach sheds new light on peptidoglycan synthesis in Escherichia coli. ChemBioChem / 2011 / 12 / 1124-1133.
Pieters, R.J. Carbohydrate mediated bacterial adhesion. Advances in Experimental Medicine and Biology / 2011 / 715 / 227-240.
Rijkers, D.T.S., Prada López, F. de, Liskamp, R.M.J. & Diederich, F. A convenient [2+2] cycloaddition-cycloreversion reaction for the synthesis of 1,1-dicyanobuta-1,3-diene-scaffolded peptides as new imaging chromophores. Tetrahedron Letters / 2011 / 52 / 6963-6967.
Rijkers, D.T.S. & Diederich, F. A convenient synthesis of new chromophoric tetracyanobutadiene-scaffolded peptides via a dipolar [2+2] cycloaddition-cycloreversion reaction. Tetrahedron Letters / 2011 / 52 / 4021-4025.
Wolf, Robert, Ehlers, A.W., Khusniyarov, M.M., Hartl, F., Bruin, B. de, Long, G.J., Grandjean, F., Schappacher, F.M., Pöttgen, R., Slootweg, J.C., Lutz, M., Spek, A.L. & Lammertsma, K. Homoleptic Diphosphacyclobutadiene Complexes [M(η4-P2C2R2)2]x- (M=Fe, Co; x=0, 1). Chemistry-A European Journal / 2011 / 16(48) / 14322-14334.
Yim, C.B., Wildt, B. van der, Dijkgraaf, I., Joosten, L., Eek, A., Versluis, C., Rijkers, D.T.S., Boerman, O.C. & Liskamp, R.M.J. Spacer effects on in vivo properties of DOTA-conjugated dimeric [Tyr3]octreotate peptides, synthesized via a 'Cu(I)-click' and 'sulfo-click' ligation method. ChemBioChem / 2011 / 12 / 750-760.
Zamora Fallas, L.G., Halkes, S.B.A., Beukelman, C.J., Berg, A.J.J. van den, Arias, M.L., Umaña, E. & Aguilar, I. Antibacteriële activiteit van de honing van angelloze bijen uit Costa Rica. Nederlands tijdschrift voor fytotherapie / 2011 / 3 / 16-18.
Zhang, J., Kemmink, J., Rijkers, D.T.S. & Liskamp, R.M.J. Cu(I)- and R(II)-mediated "click" cyclization of tripeptides toward vancomycin-inspired mimics. Organic letters / 2011 / 13 / 3438-3441.

PH.D. Thesis

Yim, C.B. (2011, januari 26).
Synthesis and evaluation of radiolabeled peptide multimers for tumor targeting.
26 januari 2011 - ISBN
Prom./coprom.: prof. dr. R.M.J. Liskamp, O.C. Boerman & dr. ir. D.T.S. Rijkers.

Publications 2010

van Ameijde J, Poot AJ, van Wandelen LTM, Wammes AE, Ruijtenbeek R, Rijkers DTS, Liskamp RMJ Preparation of novel alkylated arginine derivatives suitable for click-cycloaddition chemistry and their incorporation into pseudosubstrate- and bisubstrate-based kinase inhibitors. Org Biomol Chem. / 2010 Apr / 7;8(7) / 1629-39
Ameijde J van, Slot TK, Liskamp RMJ Towards the synthesis of sylfonamide based RNA mimetics. Tetrahedron-Asymmetry / 2010 / 21 / 469
Arnusch, CJ, Ippel, JH, Kooijman, H, Spek, AL, Liskamp, RMJ, Kemmink, J, Pieters, RJ Direct structural comparison of a rigid cyclic peptidic scaffold using crystallography and NMR in strained PH polymer gels. European Journal of Organic Chemistry / 2010 / 4501-4507
Bunschoten A, Feitsma LJ, Kruijtzer JAW, de Haas CJ, Liskamp RMJ, Kemmink J CHIPS binds to the phosphorylated N-terminus of the C5a-receptor. Bioorg Med Chem Lett. / 2010 Jun 1 / 20(11) / 3338-40
Bunschoten A, Ippel JH, Kruijtzer JAW, Feitsma L, de Haas CJ, Liskamp RMJ, Kemmink J A peptide mimic of the chemotaxis inhibitory protein of Staphylococcus aureus: towards the development of novel anti-inflammatory compounds. Amino Acids / 2010 Aug
Dekker FJ, Mol NJ, Liskamp RMJ Thermodynamics of phosphotyrosine peptide-peptoid hybrids binding to the p56lck SH2 domain. J Pept Sci. / 2010 Jul / 16(7) / 322-8
van Dijk M, van Nostrum CF, Hennink WE, Rijkers DTS, Liskamp RMJ Synthesis and characterization of enzymatically biodegradable PEG and peptide-based hydrogels prepared by click chemistry. Biomacromolecules / 2010 Jun 14 / 11(6) / 1608-14
Dijk, M van, Postma TM, Rijkers DTS, Liskamp RMJ, Nostrum CF, Hennink WE Synthesis and characterization of tailorable biodegradable thermoresponsive methacryloylamide polymers based on L-serine and L-threonine alkyl esters. Polymer / 2010 / 55 / 2479-2485
Hell, AJ van, Klymchenko, A, Burgers, PPM, Moret, EE, Jiskoot, W, Hennink, W.E., Crommelin, D.J.A. & Mastrobattista, E Conformation and intermolecular interactions of SA2 peptides self-assembled into vesicles. Journal of Physical Chemistry B / 2010 / 114(34) / 11046-52
Khemtémourian L, Engel MF, Liskamp RMJ, Höppener JW, Killian JA The N-terminal fragment of human islet amyloid polypeptide is non-fibrillogenic in the presence of membranes and does not cause leakage of bilayers of physiologically relevant lipid composition. Biochim Biophys Acta. / 2010 Sep / 1798(9) / 1805-11
Khemtémourian L, Engel MF, Kruijtzer JAW, Höppener JW, Liskamp RMJ, Killian JA The role of the disulfide bond in the interaction of islet amyloid polypeptide with membranes. Eur Biophys J. / 2010 Aug / 39(9) / 1359-64
Koops, W, Liskamp, RMJ titel 2. Men's health / 2010
Kuil, J, Fischer, MJE, Mol, NJ de, Liskamp, RMJ Cell permeable ITAM constructs for the modulation of mediator release in mast cells. Organic & Biomolecular Chemistry / 2010
Lakowski, TM, Hart, P 't, Ahern, CA, Martin, NI, Frankel, A N-eta-Substituted arginyl peptide inhibitors of protein arginine N-methyltransferases. ACS Chemical Biology / 2010 / 5 / 1053-1063
Nuijens, T, Cusan, C, Schepers, AHM & Quaedflieg, PJLM Enzymatic synthesis of C-terminally activated peptide esters and their use in industrial chemi-enzymatic peptide synthesis. Journal of peptide science / 2010 / 16 / 44-47
Nuijens, T, Cusan, C, Dooren, TJGM van, Moody, HM, Merkx, NSM, Kruijtzer, JAW, Rijkers, DTS, Liskamp, RMJ, Quaedflieg, PJLM Fully enzymatic peptide synthesis using C-terminal tert-butyl ester interconversion. Advanced synthesis & catalysis / 2010 / 352 / 2399-2404
Parera Pera NP, Kouki A, Haataja S, Branderhorst HM, Liskamp RMJ, Visser GM, Finne J, Pieters RJ Detection of pathogenic Streptococcus suis bacteria using magnetic glycoparticles. Org Biomol Chem. / 2010 May / 21;8(10) / 2425-9
Parera Pera N, Branderhorst HM, Kooij R, Maierhofer C, van der Kaaden M, Liskamp RMJ, Wittmann V, Ruijtenbeek R, Pieters RJ Rapid screening of lectins for multivalency effects with a glycodendrimer microarray. Chembiochem / 2010 Sep 3 / 11(13) / 1896-904
Pieters, RJ Towards multivalent carbohydrate drugs . Drug Discovery Today: Technologie / 2009 / 6 / e27-e31
Ramadurai, S, Holt, A, Schäfer, LV, Krasnikov, VV, Rijkers, DTS, Marrink, SJ, Killian, JA, Poolman, B Influence of hydrophobic mismatch and amino acid composition on the lateral diffusion of transmembrane peptides. Biophysical Journal / 2010 / 99 / 1447-1454
Rijkers DTS, Merkx R, Yim CB, Brouwer AJ, Liskamp RMJ 'Sulfo-click' for ligation as well as for site-specific conjugation with peptides, fluorophores, and metal chelators. Pept Sci. / 2010 Jan / 16(1) / 1-5
van Scherpenzeel M, van den Berg RJ, Donker-Koopman WE, Liskamp RMJ, Aerts JM, Overkleeft HS, Pieters RJ Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase. Bioorg Med Chem. / 2010 Jan 1 / 18(1) / 267-73
Verheul, RJ, Wal, S van der, Hennink, WE Tailorable thiolated trimethyl chitosans for covalently stabilized nanoparticles. Biomacromolecules / 2010 / 11 / 1965-1971
Verheyen, E, Delain-Bioton, L, Wal, S van der, Morabit, N el, Barendregt, A, Hennink, WE, Nostrum, CF van Conjugation of methacrylamide groups to a model protein via a reducible linker for immobilization and subsequent triggered release from hydrogels. Macromolecular Bioscience / 2010 / 10(12) / 1517-26
Yim CB, Dijkgraaf I, Merkx R, Versluis C, Eek A, Mulder GE, Rijkers DTS, Boerman OC, Liskamp RMJ Synthesis of DOTA-conjugated multimeric [Tyr3]octreotide peptides via a combination of Cu(I)-catalyzed "click" cycloaddition and thio acid/sulfonyl azide "sulfo-click" amidation and their in vivo evaluation. J Med Chem. / 2010 May / 27;53(10) / 3944-53

Ph.D. Thesis

M. van Scherpenzeel
Carbohydrate - based chemical probes for the proteomic profiling of glucosidases and the emerging cancer marker galectin-3
15 februari 2010 - ISBN 978-90-393-5274-8
Prom./coprom.: Prof.dr. R.M.J. Liskamp & Dr. R.J. Pieters

A.J. Poot
Chemical Phosphoproteomics and Development of Bisubstrate Based Inhibitors of Protein Kinase C Isozymes
19 mei 2010 - ISBN 978-90-393-5328-8
Prom./coprom.: Prof.dr. R.M.J. Liskamp & Dr. ir. D.T.S. Rijkers, Dr. M. Slijper

A. Bunschoten
Synthesis and Interactions of Sulfated C5a-receptor and CHIPS Mimics
30 augustus 2010- ISBN 978-90-8891-190-3
Prom./coprom.: Prof.dr. R.M.J. Liskamp & Dr. J. Kemmink, Dr. ir. J.A.W. Kruijtzer

Publications 2009

Albada, H.B., Arnusch, C.J., Branderhorst, H.M., Verel, A.M., Janssen, W.T.M., Breukink, E.J., Kruijff, B. de, Pieters, R.J. & Liskamp, R.M.J. Potential scorpionate antibiotics: targeted hydrolysis of lipid II containing model membranes by vancomycin-TACzyme conjugates and modulation of their antibacterial activity by Zn-ions. Bioorganic & Medicinal Chemistry Letters / 2009 / 19 / 3721-3724.
Bunschoten, A., Kruijtzer, J.A.W., Ippel, J.H., Haas, C.J.C. de, Strijp, J.A.G. van, Kemmink, J. & Liskamp, R.M.J. A general sequence independent solid phase method for the site specific synthesis of multiple sulfated-tyrosine containing peptides. Chemical Communications / 2009 / 21 / 2999-3001.
Chamorro, M.C., Kruijtzer, J.A.W., Farsaraki, M., Balzarini, J. & Liskamp, R.M.J. A general approach for the non-stop solid phase synthesis of TAC-scaffolded loops towards protein mimics containing discontinous epitopes. Chemical Communications / 2009 / 7 / 821-823.
Dijk, M. van, Rijkers, D.T.S., Liskamp, R.M.J., Nostrum, C.F. van & Hennink, W.E. Synthesis and applications of biomedical and pharmaceutical polymers via click chemistry methodologies. Bioconjugate Chemistry / 2009 / 20 / 2001-2016.
Elgersma, R.C., van Dijk, M., Dechesne, A.C., van Nostrum, C.F., Hennink, W.E., Rijkersa, D.T.S. & Liskamp, R.M.J. Microwave-assisted click polymerization for the synthesis of A beta(16-22) cyclic oligomers and their self-assembly into polymorphous aggregates. Organic & Biomolecular Chemistry / 2009 / 7(21) / 4517-4525.
Gubbens, J., Ruijter, E., Fays, L.E.V., Damen, J.M.A., Kruijff, B. de, Slijper, M., Rijkers, D.T.S., Liskamp, R.M.J. & Kroon, A.I.P.M. de. Photocrosslinking and click chemistry enable the specific detection of proteins interacting with phospholipids at the membrane interface. Chemistry & Biology/ 2009 / 3-14.
Holt, A., Koehorst, R.B.M., Rutters-Meijneke, T., Gelb, M.H., Rijkers, D.T.S., Hemminga, M.A. & Killian, J.A. Tilt and rotation angles of a transmembrane model peptide as studied by fluorescence spectroscopy. Biophysical Journal / 2009 / 97 / 2258-2266.
Ippel, J.H., Haas, C.J.C. de, Bunschoten, A., Strijp, J.A.G. van, Kruijtzer, J.A.W., Liskamp, R.M.J. & Kemmink, J. Structure of the tyrosine-sulfated C5a receptor N terminus in complex with chemotaxis inhibitory protein of staphylococcus aureus. Journal of Biological Chemistry / 2009 / 284 / 12363-12372.
Koppen, A., Houtman, R., Pijnenburg, D., Jeninga, E.H., Ruijtenbeek, R. & Kalkhoven, E. Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor. Molecular & Cellular Proteomics / 2009 / 8(10) / 2212-2226.
Kuil J, Branderhorst HM, Pieters RJ, de Mol NJ, Liskamp RM. ITAM-derived phosphopeptide-containing dendrimers as multivalent ligands for Syk tandem SH2 domain. Org Biomol Chem. / 2009 Oct 7 / 7(19) / 4088-94. PubMed PDF [Graphical Abstract 2009]
Kuil J, van Wandelen LT, de Mol NJ, Liskamp RM. Switching between low and high affinity for the Syk tandem SH2 domain by irradiation of azobenzene containing ITAM peptidomimetics. J Pept Sci. / 2009 Oct / 15(10) / 685-91. PubMed PDF
Poot AJ, van Ameijde J, Slijper M, van den Berg A, Hilhorst R, Ruijtenbeek R, Rijkers DT, Liskamp RM. Development of selective bisubstrate-based inhibitors against protein kinase C (PKC) isozymes by using dynamic peptide microarrays. Chembiochem. / 2009 Aug 17 / 10(12) / 2042-51. PubMed PDF
van Dijk M, Rijkers DT, Liskamp RM, van Nostrum CF, Hennink WE. Synthesis and Applications of Biomedical and Pharmaceutical Polymers via Click Chemistry Methodologies. Bioconjug Chem. / 2009 Jul 17. PubMed PDF
Yim CB, Boerman OC, de Visser M, de Jong M, Dechesne AC, Rijkers DT, Liskamp RM. Versatile conjugation of octreotide to dendrimers by cycloaddition ("click") chemistry to yield high-affinity multivalent cyclic Peptide dendrimers. Bioconjug Chem. / 2009 Jul / 20(7) / 1323-31. PubMed PDF
Nuijens T, Cusan C, Kruijtzer JA, Rijkers DT, Liskamp RM, Quaedflieg PJ. Enzymatic synthesis of C-terminal arylamides of amino acids and peptides. J Org Chem. / 2009 Aug 7 / 74(15) / 5145-50. PubMed PDF
Bauke Albada H, Arnusch CJ, Branderhorst HM, Verel AM, Janssen WT, Breukink E, de Kruijff B, Pieters RJ, Liskamp RM. Potential scorpionate antibiotics: targeted hydrolysis of lipid II containing model membranes by vancomycin-TACzyme conjugates and modulation of their antibacterial activity by Zn-ions. Bioorg Med Chem Lett. / 2009 Jul 15 / 19(14) / 3721-4. PubMed PDF
van Scherpenzeel M, Moret EE, Ballell L, Liskamp RM, Nilsson UJ, Leffler H, Pieters RJ. Synthesis and evaluation of new thiodigalactoside-based chemical probes to label galectin-3. Chembiochem. / 2009 Jul 6 / 10(10) / 1724-33. PubMed PDF
Bunschoten A, Kruijtzer JA, Ippel JH, de Haas CJ, van Strijp JA, Kemmink J, Liskamp RM. A general sequence independent solid phase method for the site specific synthesis of multiple sulfated-tyrosine containing peptides. Chem Commun (Camb). / 2009 Jun 7 / (21) / 2999-3001 PubMed PDF
Harmsen RA, Ghalit N, Kemmink J, Hilbers HW, Breukink E, Rijkers DT, Liskamp RM. Alkene/alkane-bridged mimics of the lantibiotic nisin: toward novel peptide-based antibiotics. Adv Exp Med Biol. / 2009 / 611 / 533-4. PubMed
Elgersma RC, Rijkers DT, Liskamp RM. pH controlled aggregation morphology of Abeta(16-22): formation of peptide nanotubes, helical tapes and amyloid fibrils. Adv Exp Med Biol. / 2009 / 611 / 239-40 PubMed
Kuil J, van Wandelen LT, de Mol NJ, Liskamp RM. Peptidomimetic ligands for the tandem SH2 domain of the Syk protein involved in signal transduction. Adv Exp Med Biol. / 2009 / 611 / 81-2. PubMed
Chamorro C, Kruijtzer JA, Farsaraki M, Balzarini J, Liskamp RM. A general approach for the non-stop solid phase synthesis of TAC-scaffolded loops towards protein mimics containing discontinuous epitopes. Chem Commun (Camb) / 2009 Feb 21 / (7) / 821-3. PubMed PDF
Ippel JH, de Haas CJ, Bunschoten A, van Strijp JA, Kruijtzer JA, Liskamp RM, Kemmink J. Structure of the tyrosine-sulfated C5a receptor N terminus in complex with chemotaxis inhibitory protein of Staphylococcus aureus. J Biol Chem. / 2009 May 1 / 284(18) / 12363-72. PubMed PDF
Gubbens J, Ruijter E, de Fays LE, Damen JM, de Kruijff B, Slijper M, Rijkers DT, Liskamp RM, de Kroon AI. Photocrosslinking and click chemistry enable the specific detection of proteins interacting with phospholipids at the membrane interface. Chem Biol. / 2009 Jan 30 / 16(1) / 3-14. PubMed
Teertstra WR, van der Velden GJ, de Jong JF, Kruijtzer JA, Liskamp RM, Kroon-Batenburg LM, Müller WH, Gebbink MF, Wösten HA. The filament-specific Rep1-1 repellent of the phytopathogen Ustilago maydis forms functional surface-active amyloid-like fibrils. J Biol Chem / 2009 Apr 3 / 284(14) / 9153-9. PubMed PDF
Martin N.I. Concise preparation of tetra-orthogonally protected (2,S6R)-lanthionines. Journal of Organic Chemistry / 2009 / 74 / 946-949. PubMed

Ph.D. Thesis

N.S.M. Merkx.
Application of Azides in Chemoselective Amidation Reactions.
14 april 2009 - ISBN 978-90-393-5025-6.
Prom./coprom.: Prof.dr. R.M.J. Liskamp & Dr. ir. D.T.S. Rijkers

Dijk, M. van
New Biodegradable Peptide-based Polymer Constructs.
5 oktober 2009 - ISBN 978-90-393-5165-9.
Prom./coprom.: prof. dr. R.M.J. Liskamp, prof. dr. ir. W.E. Hennink, dr. ir. D.T.S. Rijkers & dr. C.F. van Nostrum.

Kuil, J.
Peptidomimetic ligands for the tandem SH2 domain of Syk kinase.
18 november 2009 - ISBN 978-90-902-4696-3. Prom./coprom.: prof. dr. R.M.J. Liskamp & dr. N.J. de Mol.

Albada, H.B.
Enzyme active site mimics based on TriAzaCyclophane (TAC)-scaffolded peptides and amino acid residues.
21 december 2009 - ISBN 978-90-393-5248-9. Prom./coprom.: prof. dr. R.M.J. Liskamp.

Publications 2008

Albada, H.B. & Liskamp, R.M.J. TAC-scaffolded tripeptides as artificial hydrolytic receptors: a combinatorial approach toward esterase mimics. Journal of Combinatorial Chemistry / 2008 / 10 / 814-824 . PubMed PDF [Graphical Abstract 2008]
Arnusch, C.J., Bonvin, A.M.J.J., Verel, A.M., Jansen, W.T.M., Liskamp, R.M.J., Kruijff, B. de, Pieters, R.J. & Breukink, E.J. The vancomycin-nisin(1-12) hybrid restores activity against vancomycin resistant enterococci. Biochemistry / 2008 / 47(48) / 12661-12663. PubMed PDF
Berg AJ van den, van den Worm E, van Ufford HC, Halkes SB, Hoekstra MJ, Beukelman CJ. An in vitro examination of the antioxidant and anti-inflammatory properties of buckwheat honey. J Wound Care / 2008 Apr / 17(4) / 172-4, 176-8. PubMed
Beukelman CJ, van den Berg AJ, Hoekstra MJ, Uhl R, Reimer K, Mueller S. Anti-inflammatory properties of a liposomal hydrogel with povidone-iodine (Repithel) for wound healing in vitro. Burns / 2008 Sep / 34(6) / 845-55. Epub 2008 Apr 18. PubMed PDF
Branderhorst HM, Ruijtenbeek R, Liskamp RM, Pieters RJ. Multivalent carbohydrate recognition on a glycodendrimer-functionalized flow-through chip. Chembiochem / 2008 Jul 21 / 9(11) / 1836-44. PubMed PDF
Branderhorst HM, Kooij R, Salminen A, Jongeneel LH, Arnusch CJ, Liskamp RM, Finne J, Pieters RJ. Synthesis of multivalent Streptococcus suis adhesion inhibitors by enzymatic cleavage of polygalacturonic acid and 'click' conjugation. Org Biomol Chem. / 2008 Apr 21 / 6(8) / 1425-34. Epub 2008 Feb 29. PubMedPDF
Brouwer AJ, Elgersma RC, Jagodzinska M, Rijkers DT, Liskamp RM. Delayed fibril formation of amylin(20-29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis. Bioorg Med Chem Lett. / 2008 Jan 1 / 18(1) / 78-84. Epub 2007 Nov 6. PubMedPDF [Graphical Abstract 2008]
Carstens, M.G., Jong, P.H.J.L.F de, Nostrum, C.F. van, Kemmink, J., Verrijk, R., Leede, L. de, Crommelin, D.J.A. & Hennink, W.E. The effect of core composition in biodegradable oligomeric micelles as taxane formulations. European Journal of Pharmaceutics and Biopharmaceutics / 2008 / 68 / 596-606.PubMed
Cerqueira F, Cidade H, van Ufford L, Beukelman C, Kijjoa A, Nascimento MS. The natural prenylated flavone artelastin is an inhibitor of ROS and NO production. Int Immunopharmacol / 2008 Apr / 8(4) / 597-602. Epub 2008 Jan 15. PubMedPDF
Dijk, M. van, Nollet, A., Weijers, P., Dechesne, A., Nostrum, C.F. van, Hennink, W.E., Rijkers, D.T.S. & Liskamp, R.M.J. Synthesis and characterization of biodegradable peptide-based polymers prepared by microwave-assisted click chemistry. Biomacromolecules/ 2008 / 9 / 2834-2843. PubMed
Elgersma, R.C., Mulder, G.E., Posthuma, G., Rijkers, D.T.S. & Liskamp, R.M.J. Mirror image supramolecular helical tapes formed by the enantiomeric-depsipeptide derivatives of the amyloidogenic peptide amylin (20-29). Tetrahedron Letter / 2008 / 49(6) / 987-991.
Groenendaal, B., Ruijter, E., Kanter, F.J.J. de, Lutz, M., Spek, A.L. & Orru, R.V.A. Generation of molecular diversity using a complexity-generating MCR-platform towards triazinane diones. Organic & Biomolecular Chemistry / 2008 / 6 / 3158-3165.
Holt, A., Almeida, R.F.M. de, Nyholm, T.K.M., Loura, L.M.S., Daily, A.E., Staffhorst, R.W.H.M., Rijkers, D.T.S., Koeppe, R.E., Prieto, M. & Killian, J.A. Is there a preferential interaction between cholesterol and tryptophan residues in membrane proteins? Biochemistry / 2008 / 47 / 2638-2649. PubMed
Ingen H. van, van Schaik FM, Wienk H, Ballering J, Rehmann H, Dechesne AC, Kruijzer JA, Liskamp RM, Timmers HT, Boelens R. Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3. Structure / 2008 Aug 6 / 16(8) / 1245-56. PubMed PDF
Kuil J, van Wandelen LT, de Mol NJ, Liskamp RM. A photoswitchable ITAM peptidomimetic: synthesis and real time surface plasmon resonance (SPR) analysis of the effects of cis-trans isomerization on binding. Bioorg Med Chem. / 2008 Feb 1 / 16(3) / 1393-9. Epub 2007 Oct 22. PubMedPDF [Graphical Abstract 2008]
Leemhuis, M., Akeroyd, N., Kruijtzer, J.A.W., Nostrum, C.F. van & Hennink, W.E. Synthesis and characterization of allyl functionalized poly??-hydroxy)acids and their further dihydroxylation and epoxidation. European polymer journal / 2008 / 44 / 308-317.
Martin, N.I., Beeson, W.T., Woodward, J.J. & Marletta, M.A. NG-aminoguanidines from primary amines and the preparation of nitric oxide synthase inhibitors. Journal of Medicinal Chemistry / 2008 / 51 / 924-931. Pubmed PDF
Martin, N.I.* and Liskamp R.M.J. Preparation of NG-Substituted L-Arginine Analogues Suitable for Solid Phase Peptide Synthesis ASAP J. Org. Chem. / August 28, 2008 / ASAP Article, 10.1021/jo801517fPubmed PDF [Graphical Abstract 2008]
Özdirekcan, S., Nyholm, T.K.M., Raja, M., Rijkers, D.T.S., Liskamp, R.M.J. & Killian, J.A. Influence of trifluoroethanol on membrane interfacial anchoring interactions of transmembrane alpha-helical peptides. Biophysical Journal / 2008 / 94 / 1315-1325.
Pieters, R.J. & Liskamp, R.M.J. Multivalent presentation strategies in novel inhibitors of bacterial (toxin) adhesion and synthetic vaccines. Anti-Infective Agents in Medicinal Chemistry / 2008 / 7 / 193-200.
Verheul, R.J., Amidi, M., Wal, S. van der, Riet, E. van, Jiskoot, W. & Hennink, W.E. Synthesis, characterization and in vitro biological properties of O-methyl free N,N,N-trimethylated chitosan. Biomaterials / 2008 / 29 / 3642-3539. PubMed PDF

Ph.D. Thesis

Branderhorst H.M.
Design, synthesis and evaluation of multivalent glycodendrimers as multivalent ligands
2 december 2008 - ISBN 978-90-9023532-5.
Prom./coprom.: Prof.dr. R.M.J. Liskamp & Dr. R.J. Pieters

Elgersma R.C.
Amyloidogenic peptides for design of inhibitors of peptide aggregation and as templates for new bionanomaterials.
29 oktober 2008 - ISBN 978-90-393-4889-5.
Prom./coprom: Prof.dr. R.M.J. Liskamp & Dr.ir. D.T.S. Rijkers.

Zoelen D.J. van
Mimicry of Discontious Epitopes Employing the Triazacyclophane (TAC) Scaffold for Modulations of Protein-Protein Interactions
27 maart 2008- ISBN 978-90-393-4776-8.
Prom./coprom.: Prof.dr. R.M.J. Liskamp.

Publications 2007

Arnusch CJ, Branderhorst H, de Kruijff B, Liskamp RM, Breukink E, Pieters RJ. Enhanced membrane pore formation by multimeric/oligomeric antimicrobial peptides. Biochemistry / 2007 Nov 20 / 46(46):13437-42. Epub 2007 Oct 18. PubMed PDF
Branderhorst HM, Liskamp RM, Visser GM, Pieters RJ. Strong inhibition of cholera toxin binding by galactose dendrimers. Chem Commun (Camb). / 2007 Dec 21 / (47):5043-5. Epub 2007 Sep 24. PubMed PDF
Albada HB, Soulimani F, Weckhuysen BM, Liskamp RM. Scaffolded amino acids as a close structural mimic of type-3 copper binding sites. Chem Commun (Camb). / 2007 Dec 14 / (46):4895-7. PubMed
R.J. Pieters, D.T.S. Rijkers and R.M.J. Liskamp. Application of the 1,3-dipolarcycloaddition reaction in chemical biology: approaches toward multivalent carbohydrates and peptides and peptide-based polymers. QSAR Comb Sci 26 / (2007) / 1181-1190 PDF
van Zoelen DJ, Egmond MR, Pieters RJ, Liskamp RM. Synthesis and evaluation of TAC-based inhibitors of papain as mimics of cystatin B. Chembiochem / 2007 Nov 5 / 8 / (16):1950-6. PubMed PDF
Brouwer AJ, Bunschoten A, Liskamp RMJ. Synthesis and evaluation of chloromethyl sulfoxides as a new class of selective irreversible cysteine protease inhibitors. Bioorg Med Chem. / 2007 Nov 15 / 15/ (22):6985-93. Epub 2007 Aug 22.PubMed PDF [Graphical Abstract 2007]
Hijnen M, van Zoelen DJ, Chamorro C, van Gageldonk P, Mooi FR, Berbers G, Liskamp RMJ. A novel strategy to mimic discontinuous protective epitopes using a synthetic scaffold. Vaccine. / 2007 Sep 17 / 25 / (37-38):6807-17. Epub 2007 Jul 26. PubMed PDF
Pukin AV, Branderhorst HM, Sisu C, Weijers CA, Gilbert M, Liskamp RM, Visser GM, Zuilhof H, Pieters RJ. Strong inhibition of cholera toxin by multivalent GM1 derivatives.Chembiochem. / 2007 Sep 3 / 8 / (13):1500-3. No abstract available. PubMedPDF
A.J. Brouwer, R.C. Elgersma, M. Jagodzinska, D.T.S. Rijkers and R.M.J. Liskamp. Delayed fibril formation of amylin(20-29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis. Bioorg Med Chem Lett / 2007 / DOI:10.1016/j.bmcl.2007.11.009
S. Özdirekcan, T.K.M. Nyholm, M. Raja, D.T.S. Rijkers, R.M.J. Liskamp and J.A. Killian. Influence of trifluoroethanol on membrane interfacial anchoring interactions of transmembrane alfa-helical peptides. Biophys J / 2007 / DOI:10.1529/biophysj.106.101782
R.C. Elgersma, G. Posthuma, D.T.S. Rijkers and R.M.J. Liskamp. Backbone-modified amylin derivatives: implications for amyloid inhibitor design and as template for self-assembling bionanomaterials. J Peptide Sci / 2007 / 13 / 709-716 PDF
N. Ghalit, J.F. Reichwein, H.W. Hilbers, E. Breukink, D.T.S. Rijkers and R.M.J. Liskamp. Synthesis of bicyclic alkene-/alkane-bridged nisin mimics by ring-closing metathesis and their biochemical evaluation as lipid II binders: toward the design of potential novel antibiotics. ChemBioChem / 2007 / 8 / 1540-1554 PDF [Graphical Abstract 2007]
Merkx R, Haren MJ, Rijkers DTS, Liskamp RMJ. Resin-bound sulfonyl azides: efficient loading and activation strategy for the preparation of the N-acyl sulfonamide linker. J Org Chem. / 2007 Jun 8 / 72 / (12):4574-7. Epub 2007 May 12. HTMLPDF [Graphical Abstract 2007]
de Planque MR, Raussens V, Contera SA, Rijkers DTS, Liskamp RMJ, Ruysschaert JM, Ryan JF, Separovic F, Watts A. Beta-Sheet structured beta-amyloid(1-40) perturbs phosphatidylcholine model membranes. J Mol Biol. / 2007 May 11 / 368(4) :982-97. Epub 2007 Mar 2. PubMed PDF
E.E. Kooijman, D.P. Tieleman, C. Testerink, T. Munnik, D.T.S. Rijkers, K.N.J. Burger and B. de Kruijff. An electrostatic/hydrogen bond switch as the basis for the specific interaction of phosphatidic acid with proteins. J Biol Chem 282 / 2007 / 11356-11364 HTML PDF
Elgersma RC, Mulder GE, Kruijtzer JAW, Posthuma G, Rijkers DTS, Liskamp RMJ. Transformation of the amyloidogenic peptide amylin(20-29) into its corresponding peptoid and retropeptoid: access to both an amyloid inhibitor and template for self-assembled supramolecular tapes. Bioorg Med Chem Lett. / 2007 Apr 1 / 17(7) :1837-42. Epub 2007 Jan 24. PubMedPDF [Graphical Abstract 2007]
I. Dijkgraaf, A.Y. Rijnders, A. Soede, A.C. Dechesne, G.W. van Esse, A.J. Brouwer, F.H.M. Corstens, O.C. Boerman, D.T.S. Rijkers and R.M.J. Liskamp. Synthesis of DOTA-conjugated multivalent cyclic-RGD peptide dendrimers via 1,3-dipolar cycloaddition and their biological evaluation: implications for tumor targeting and tumor imaging purposes. Org Biomol Chem/ 2007 / 5 / 935-944 PDF Elsevier [Graphical Abstract 2007]
Ghalit N, Kemmink J, Hilbers HW, Versluis C, Rijkers DTS, Liskamp RMJ. Step-wise and pre-organization induced synthesis of a crossed alkene-bridged nisin Z DE-ring mimic by ring-closing metathesis. Org Biomol Chem. / 2007 Mar 21 / 5(6) / 924-34. Epub 2007 Feb 7. PDF [Graphical Abstract 2007]
Dijk M, Mustafa K, Dechesne AC, Nostrum CF, Hennink WE, Rijkers DTS, Liskamp RMJ. Synthesis of peptide-based polymers by microwave-assisted cycloaddition backbone polymerization. Biomacromolecules./ 2007 Feb / 8(2) / 327-30. PDF [Graphical Abstract 2007]

Ph.D. Thesis:

H.T. ten Brink.
New Synthetic Routes towards Constrained Cyclic Peptides Inspired by Vancomycin.
2007, January 22
Prom./coprom.: Prof.dr. R.M.J. Liskamp, Dr. ir. D.T.S. Rijkers.

Publications 2006

Ambroggio, E.E., Villarreal, M.A., Montich, G.G., Rijkers, D.T.S., Planque, M.R.R. de, Separovic, F., & Fidelio, G.D. Interfacial properties of the M1 segment of the nicotinic acetylcoline receptor. Biophysical Chemistry / 2006 / 121 / 171-176.
Ballell Pages, L., Scherpenzeel, M. van, Buchalova, K., Liskamp, R.M.J., & Pieters, R.J.M. A new chemical probe for the detection of the cancer-linked galectin-3. Organic & Biomolecular Chemistry / 2006 / 4 / 4387-4394. DOI: 10.1039/b611050a [Graphical Abstract 2006]
Brink, H.T. ten, Rijkers, D.T.S., & Liskamp, R.M.J. Synthesis of alkyne-bridged cyclic tripeptides toward constrained mimics of vancomycin. Journal of Organic Chemistry / 2006 / 71 / 1817-1824. PubMed PDF [Graphical Abstract 2006]
Brouwer, A.J., Merkx, N.S.M., Dabrowska, K., Rijkers, D.T.S., & Liskamp, R.M.J. Synthesis and applications of ß-aminoethanesulfonyl azides. Synthesis-Stuttgart / 2006 / 455-460.
Dijkgraaf, I., Kruijtzer, J.A.W., Frielink, C., Corstens, F.H.M., Oyen, W.J.G., Liskamp, R.M.J., & Boerman, O.C. alphavß3 integrin-targeting of intraperitoneally growing tumors with radiolabeled RGD peptide. alpha(v)beta(3) Integrin-targeting of intraperitoneally growing tumors with a radiolabeled RGD peptide. International Journal of Cancer/ 2006 Nov 9 / 120 / 605-610Int J Cancer /PubMed
Dijkgraaf, I., Kruijtzer, J.A.W., Frielink, C., Soede, A.C., Hilbers, H.W., Oyen, W.J.G., Corstens, F.H.M., Liskamp, R.M.J., & Boerman, O.C. Synthesis and biological evaluation of potent alphavß3-integrin receptor antagonists. Nuclear medicine and biology / 2006 / 33 / 953-961.
Dirksen, E.H.C., Pinkse, M.W.H., Rijkers, D.T.S., Cloos, J, Liskamp, R.M.J., Slijper, M., & Heck, A.J.R. Investigating the dynamic nature of the interactions between nuclear proteins and histones upon DNA damage using an immobilized peptide chemical proteomics approach. Journal of Proteome Research / 2006 / 5 / 2380-2388. PubMed PDF
Elgersma, R.C., Meijneke, T., Posthuma, G., Rijkers, D.T.S., & Liskamp, R.M.J. Self-assembly of amylin(20-29) amide bond derivatives to helical ribbons and peptide nanotubes rather than fibril formation. Chemical European Journal / 2006 / 12 / 3714-3725. PubMed PDF
Elgersma, R.C., Meijneke, T., Jong, R. de, Brouwer, A.J., Posthuma, G., Rijkers, D.T.S., & Liskamp, R.M.J. Synthesis and structural investigations of N-alkylated ß-peptidosulfonamide-peptode hybrids of the amyloidogenic amylin(20-29) sequence: implications of supramolecular folding for the design of peptide-based bionanomaterials. Organic & Biomolecular Chemistry / 2006 / 4 / 3587-3597. PubMed PDF
Engel, M.F.M., Yigittop, H., Elgersma, R.C., Rijkers, D.T.S., Liskamp, R.M.J., Kruijff, B. de, Hoppener, J.W.M., & Killian, J.A. Islet amyloid polypeptide inserts into phospholipid monolayers as monomer. Journal of Molecular Biology / 2006 / 356 / 783-789. PubMed PDF
Ghalit, N., Rijkers, D.T.S., & Liskamp, R.M.J. Alkene- and alkyne-bridged mimics of nisin as potential peptide-based antibiotics. Journal of Molecular Catalysis A-Chemical / 2006 / 254 / 68-77.
Kasyanov, V., Isenburg, J., Draughn, R.A., Hazard, S., Hodde, J., Ozolanta, I., Murovska, M., Halkes, S.B.A., Vrasidas, I., Liskamp, R.M.J., Pieters, R.J., Simionescu, D., Markwald, R.R., & Mironov, V. Tannic acid mimicking dendrimers as small intestine submucosa stabilizing nanomordants. Biomaterials / 2006 / 27 / 745-751.
Leemhuis, M., Nostrum, C.F. van, Kruijtzer, J.A.W., Zhong, Z.Y., Breteler, M.R. ten, Dijkstra, P.J., Feijen, J., & Hennink, W.E. Functionalized poly(?-hydroxyacid)s via ring-opening polymerization: toward hydrophilic polyesters with pendant hydroxyl groups. Macromolecules / 2006 / 39 / 3500-3508.
Pieters, R.J. Inhibition and detection of galectins. ChemBioChem / 2006 / 7 / 721-728.
Poot, A.J., Ruijter, E., Nuijens, T., Dirksen, E.H.C., Heck, A.J.R., Slijper, M., Rijkers, D.T.S., & Liskamp, R.M.J. Selective enrichment of Ser-/Thr-phosphorylated peptides in the presence of Ser-/Thr-glycosylated peptides. Proteomics / 2006 / 6 / 6394-6399.
Rijken, F., Kiekens, R.C.M., Worm, E. van den, Lee, P.L., Weelden, H. van, & Bruijnzeel, P.L.B. Pathophysiology of photoaging of human skin: focus on neutrophils.Photochemical & Photobiological Sciences / 2006 / 5(2) / 184-189.
van Scherpenzeel M, van der Pot M, Arnusch CJ, Liskamp RMJ, Pieters RJ. Detection of galectin-3 by novel peptidic photoprobes. Bioorg Med Chem Lett. / 2006 Oct 21 PubMed
Pieters RJ. Intervention with bacterial adhesion by multivalent carbohydrates. Med Res Rev. / 2006 Oct 4 PubMed PDF
Dijkgraaf I, Kruijtzer JAW, Liu S, Soede AC, Oyen WJ, Corstens FH, Liskamp RMJ, Boerman OC. Improved targeting of the alpha(v)beta (3) integrin by multimerisation of RGD peptides. Eur J Nucl Med Mol Imaging / 2006 Aug 15. PubMed
de Mol NJ, Catalina MI, Dekker FJ, Fischer MJE, Heck AJ, Liskamp RMJ. Protein flexibility and ligand rigidity: a thermodynamic and kinetic study of ITAM-based ligand binding to Syk tandem SH2. Chembiochem / 2005 Dec/ 6(12) / 2261-70. Pubmed

Ph.D. Thesis:

N. Ghalit.
Syntheses of Alkene / Alkyne Bridged Nisin Z Mimics as Potential Antibiotics.
2006, Juni 09 - UU Universiteit Utrecht (146 pag.).
Prom./coprom.: Prof.dr. R.M.J. Liskamp, Dr. ir. D.T.S. Rijkers.

Publications 2005

André, S., Arnusch, C.J., Kuwabara, I., Russwurm, R., Kaltner, H., Gabius, H.-J., & Pieters, R.J. Identification of peptide ligands for malignancy and growth-regulation galectins using random phage-display and designed combinatorial peptide libraries. Bioorganic & Medicinal Chemistry / 2005 / 13 / 563-573. PubMed PDF [Graphical Abstract 2005]
Appeldoorn, C.C.M., Joosten, J.A.F., Maate, F. ait el, Dobrindt, U., Hacker, J., Liskamp, R.M.J., Khan, A.S., & Pieters, R.J. Novel multivalent mannose compounds and their inhibition of the adhesion of type 1 fimbriated uropathogenic E. coli. Tetrahedron-Asymmetry / 2005 / 16 / 361-372. [Graphical Abstract 2005]
Autar, R., Liskamp, R.M.J., & Pieters, R.J. A facile synthesis of the GalNAc beta 1 -> 4Gal target sequence of respiratory pathogens. Carbohydrate research / 2005 / 340 / 2436-2442. [Graphical Abstract 2005]
Ballell Pages, L., Alink, K.J., Slijper, M., Versluis, C., Liskamp, R.M.J., & Pieters, R.J. A new chemical probe for proteomics of carbohydrate-binding proteins. ChmBioChem / 2005 / 6 / 291-295. PubMed PDF [Graphical Abstract 2005]
Benedek, O, Khan, A.S., Schneider, G., Nagy, G., Autar, R., Pieters, R.J., & Emödy, L. Identification of laminin-binding motifs of Yersinia pestis plasminogen activator by phage display. International Journal of Medical Microbiology / 2005 / 295 / 87-98. PubMed
Broekema, M., Eerd, J.J.E.M. van, Oyen, W.J.G., Corstens, F.H.M., Liskamp, R.M.J., Boerman, O.C., & Harris, T.D. Synthesis of leukotriene B4 antagonists labeled with In-111 or Tc99m to image infectious ad inflammatory foci. Journal of Medicinal Chemistry / 2005 / 48 / 6442-6453. PubMed PDF
Brouwer, A.J., & Liskamp, R.M.J. Synthesis of novel dendrimeric systems containing NLO ligands. European Journal of Organic Chemistry / 2005 / 487-495.
Catalina Caballero, M.I., Fischer, M.J.E., Dekker, F.J., Liskamp, R.M.J., & Heck, A.J.R. Binding of a diphosphorylated-ITAM peptide to spleen tyrosine kinase (Syk) induces distal conformational changes: a hydrogen exchange mass spectrometry study. Journal of the American Society for Mass Spectrometry / 2005 / 16 / 1039-1051.PubMed PDF
Duyl, B.Y. van, Meeldijk, J.D., Verkleij, A.J., Rijkers, D.T.S., Chupin, V.V., Kruijff, B. de, & Killian, J.A. A synergistic effect between cholesterol and tryptophan-flanked transmembrane helices modulates membrane curvature. Biochemistry /2005 / 44 / 4526-4532. PubMed PDF [Graphical Abstract 2005]
Eerd, J.E.M. van, Broekema, M., Harris, T.D., Edwards, D.S., Oyen, W.J.G. van, Corstens, F.H.M., & Boerman, O.C. Imaging of infection and inflammation with an improved 99m Tc-labeled LTB4 antagonist. Journal of Nuclear Medicine / 2005 / 46 / 1546-1551.
Funhoff, A.M., Nostrum, C.F. van, Lok, M.C., Kruijtzer, J.A.W., Crommelin, D.J.A., & Hennink, W.E. Cationic polymethacrylates with covalently linked membrane destabilizing peptides as gene delivery vectors. Journal of Controlled Release / 2005 / 101(1-3) / 233-246. PubMed PDF
Ghalit, N., Rijkers, D.T.S., Kemmink, J., Versluis, C., & Liskamp, R.M.J. Pre-organization induced synthesis of a crossed alkene-bridged nisin Z DE-ring mimic by ring-closing metathesis. Chemical Communications / 2005 / 192-194. PubMed PDF [Graphical Abstract 2005]
Ghalit, N., Poot, A.J., Fürstner, A., Rijkers, D.T.S., & Liskamp, R.M.J. Ring-closing alkyne metathesis approach toward the synthesis of alkyne mimics of thioether A-, B-, C-, and DE-ring systems of the lantibiotic nisin Z. Organic letters / 2005 / 7(14) / 2961-2964. PubMed PDF [Graphical Abstract 2005]
Haan, E., Wagenaar-Hilbers, J.P.A., Liskamp, R.M.J., Moret, E.E., & Wauben, M.H.M. Limited plasticity in T cell recognition of modified T cell receptor contact residues in MHC class II bound peptides. Molecular Immunology / 2005 / 42(3) / 355-364.
Haan, E., Moret, E.E., Wagenaar-Hilbers, J.P.A., Liskamp, R.M.J., & Wauben, M.H.M. Possibilities and limitations in the rational design of modified peptides for T cell mediated immunotherapy. Molecular Immunology / 2005 / 42(3) / 365-373. PubMed PDF
Haas, P.J., Haas, C.J.C. de, Poppelier, M.J.J.C., Kessel, K.P.M. van, Strijp, J.A.G. van, Dijkstra, K., Scheek, R.M., Fan, H., Kruijtzer, J.A.W., Liskamp, R.M.J., & Kemmink, J. The structure of the C5a receptor-blocking domain of chemotaxis inhibitory protein of Staphylococcus aureus is related to a group of immune evasive molecules. Journal of Molecular Biology / 2005 / 353 / 859-872.
Joosten, J.A.F., Tholen, N.T.H., Maate, F. ait el, Brouwer, A.J., Esse, G.W. van, Rijkers, D.T.S., Liskamp, R.M.J., & Pieters, R.J. (2005).High-yielding microwave-assisted synthesis of triazole-linked glycodendrimers via copper-catalyzed [3+2] cycloaddition. European Journal of Organic Chemistry / 2005 / 3182-3185. [Graphical Abstract 2005]
Kruijtzer, J.A.W., Nijenhuis, W.A.J., Wanders, N., Gispen, W.H., Liskamp, R.M.J., & Adan, R.A.H. Peptoid-peptide hybrids as potent novel melanocortin receptor ligands. Journal of Medicinal Chemistry / 2005 / 48(13) / 4224-30. PubMed PDF [Graphical Abstract 2005]
Leeuwen, S.H. van, Quaedflieg, P.J.L.M., Broxterman, Q.B., Milhajlovic, Y., & Liskamp, R.M.J. The synthesis of amides and dipeptides from unprotected amino acids by a simultaneous protection-activation strategy using boron trifluoride diethyl etherate. Tetrahedron Letters / 2005 / 46 / 653-656. [Graphical Abstract 2005]
Merkx, N.S.M., Brouwer, A.J., Rijkers, D.T.S., & Liskamp, R.M.J. Highly efficient coupling of ß-substituted aminoethane sulfonyl azides with thio acids, toward a new chemical ligation reaction. Organic letters /2005 / 7 / 1125-1128. [Graphical Abstract 2005]
Mol, N.J. de, Catalina Caballero, M.I., Dekker, F.J., Fischer, M.J.E., Heck, A.J.R., & Liskamp, R.M.J. Protein flexibility and ligand rigidity: a thermodynamic and kinetic study of ITAM based ligand binding to Syk tandem SH2. ChemBioChem / 2005 / 6/ 2261-2270. PubMed PDF [Graphical Abstract 2005]
Mol, N.J. de, Dekker, F.J., Broutin, I., Fischer, M.J.E., & Liskamp, R.M.J. Surface plasmon resonance thermodynamic and kinetic analysis as a strategic tool in drug design. Distinct ways for phosphopeptides to plug into Src- and Grb2 SH2 domains. Journal of Medicinal Chemistry / 2005 / 48 / 753-763. PubMed PDF [Graphical Abstract 2005]
Özdirekcan, S., Rijkers, D.T.S., Liskamp, R.M.J., & Killian, J.A. Influence of flanking residues on tilt and rotation angles of transmembrane peptides in lipid bilayers. A solid-state 2H NMR study. Biochemistry / 2005 / 44 / 1004-1012. PubMed PDF [Graphical Abstract 2005]
Rijkers, D.T.S., Kruijtzer, J.A.W., Killian, J.A., & Liskamp, R.M.J. A convenient solid phase synthesis of S-palmitoyl transmembrane peptides. Tetrahedron Letters / 2005 / 46 / 3341-3345. [Graphical Abstract 2005]
Rijkers, D.T.S., Esse, G.W. van, Merkx, N.S.M., Brouwer, A.J., Jacobs, J.J.F., Pieters, R.J., & Liskamp, R.M.J. Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry. Chemical Communications / 2005 / 4581-4583. PubMed PDF [Graphical Abstract 2005]
Schiffelers, R.M., Kolfschoten, S.C. van, Dijk, M. van, Scaria, P.V., Woodle, M.C., & Storm, G. siRNA as a new drug: intellectual property. Expert Opinion on Therapeutic Patents / 2005 / 15(2) / 141-152.
Sparr, E.M., Ganchev, D.N., Snel, M.M.E., Ridder, A.N.J.A., Kroon-Batenburg, L.M.J., Chupin, V.V., Rijkers, D.T.S., Killian, J.A., & Kruijff, B. de. Molecular organization in striated domains induced by transmembrane alpha-helical peptides in dipalmitoyl phosphatidylcholine bilayers. Biochemistry / 2005 / 44 / 2-10. PubMed PDF
Sparr, E.M., Ash, W.L., Nazarov, P.V., Rijkers, D.T.S., Hemminga, M.A., & Killian, J.A. Self-association of transmembrane a-helices in model membranes.Journal of Biological Chemistry / 2005 / 280 /39324-39331.
Veken, P. van der, Dirksen, E.H.C., Ruijter, E., Elgersma, R.C., Heck, A.J.R., Rijkers, D.T.S., Slijper, M., & Liskamp, R.M.J. Development of a Novel Chemical Probe for the Selective Enrichment of Phosphorylated Serine- and Threonine-Containing Peptides. ChemBioChem / 2005 / 6 / 2271-2280. PubMed PDF
Watson, J.J., Fahey, M.S., Worm, E. van den, Engels, F., Nijkamp, F.P., Stroemer, P., McMahon, S., Allen, S.J., & Dawbarn, D. TrkAd5: A novel therapeutic agent for treatment of inflammatory pain and asthma. Journal of Pharmacology and Experimental Therapeutics / 2005 PubMed PDF
Wels, B., Kruijtzer, J.A.W., Garner, K., Nijenhuis, W.A.J., Gispen, W.H., Adan, R.A.H., & Liskamp, R.M.J. Synthesis of a novel potent cyclic peptide MC4-ligand by ring-closing metathesis. Bioorganic & Medicinal Chemistry / 2005 / 13 / 4221-4227. PubMed PDF
Wels, B., Kruijtzer, J.A.W., Garner, K.M., Adan, R.A.H., & Liskamp, R.M.J. Synthesis of cyclic peptidosulfonamides as scaffolds for MC4 pharmacophoric groups. Bioorganic & Medicinal Chemistry Letters / 2005 / 15 / 287-290. PubMed PDF [Graphical Abstract 2005]

Ph.D. Thesis:

Arnusch, C.J.
Synthesis and evaluation of peptidic mimics of vancomycin and carbohydrates.
UU Universiteit Utrecht (176 pag.). 2005, maart 03
Prom./coprom.: Prof.dr. R.M.J. Liskamp, & Dr. R.J. Pieters.

Autar, R.
Synthesis of glycodendrimers and glycopolymers and their evaluation as multivalent inhibitors of bacterialadhesion.
2005, april 13 - UU Universiteit Utrecht (176 pag.).
Prom./coprom.: Prof.dr. R.M.J. Liskamp, & Dr. R.J. Pieters.

Publications 2004

Andronesi, O.C., Pfeifer, J.R., Al-Momani, L., Özdirekcan, S., Rijkers, D.T.S., Angerstein, B., Luca, S., Koert, U., Killian, J.A., & Baldus, M. Probing membrane protein orientation and structure using fast magic-angle-spinning solid-state NMR. Journal of Biomolecular NMR / 2004 / 30 / 253-265. PubMed PDF
Arnusch, C.J., Andre, S., Valentini, P., Lensch, M., Russworm, R., Siebert, H.-C., Fischer, M.J.E., Gabius, H.-J., & Pieters, R.J. Interference of the galactose-dependant binding of lectins by novel pentapeptide ligands. Bioorganic & Medicinal Chemistry Letters / 2004 / 14 / 1437-1440. [Graphical Abstract 2004]
Arnusch, C.J., & Pieters, R.J. Synthesis of a novel 14-membered highly constrained cyclic peptidic scaffold. Tetrahedron Letters / 2004 / 45 / 4153-4156. [Graphical Abstract 2004]
Arosio, D., Vrasidas, I., Valentini, P., Liskamp, R.M.J., Pieters, R.J., & Bernardi, A. Synthesis and cholera toxin binding properties of multivalent GM1 mimics.Organic & Biomolecular Chemistry 2 / 2004 / 2113-2124. PubMed PDF [Graphical Abstract 2004]
Ballell Pages, L., Joosten, J.A.F., Maate, F. ait el, Liskamp, R.M.J., & Pieters, R.J. Microwave-assisted, tin-mediated, regioselective 3-O-alkylation of galactosides. Tetrahedron Letters / 2004 / 45 / 6685-6687. [Graphical Abstract 2004]
Brink, H.T. ten, Rijkers, D.T.S., Kemmink, J., Hilbers, H.W., & Liskamp, R.M.J. (2004). Ring-closing metathesis for the synthesis of side chain knotted pentapeptides inspired by vancomycin. Organic & Biomolecular Chemistry / 2004 / 2 / 2658-2663. PubMed PDF [Graphical Abstract 2004]
Brouwer, A.J., & Liskamp, R.M.J. Synthesis of cyclic peptidosulfonamides by ring-closing metathesis.Journal of Organic Chemistry / 2004 / 69 / 3662-3668. PubMed PDF
Catalina Caballero, M.I., Mol, N.J. de, Fischer, M.J.E., & Heck, A.J.R. Probing factors affecting the gas phase stabilities of noncovalent complexes formed by peptides bound to the Grb2 SH2 domain protein. PCCP : Physical Chemistry Chemical Physics / 2004 / 6 / 2572-2579.
Chamorro, M.C., Hofman, J-W., & Liskamp, R.M.J. Combinatorial solid-phase synthesis and screening of a diverse tripodal triazacyclophane (TAC)-based synthetic receptor library showing a remarkable selectivity towards a D-Ala-D-Ala containing ligand. Tetrahedron / 2004 / 60 / 8691-8697. [Graphical Abstract 2004]
Chamorro, M.C., & Liskamp, R.M.J. Selection of synthetic receptors capable of sensing the difference in binding of D-Ala-D-Ala or D-Ala-D-Lac ligands by screening of a combinatorial CTV-based library. Tetrahedron / 2004 / 60 / 11145-11157. PDF [Graphical Abstract 2004]
Ganchev, D.N., Rijkers, D.T.S., Snel, M.M.E., Killian, J.A., & Kruijff, B. de. Strength of integration of transmembrane alpha-helical peptides in lipid bilayers as determined by Atomic Force Spectroscopy. Biochemistry /2004 / 43 (47) / 14987-14993. PubMed PDF
Haan, E., Wauben, M.H.M., Wagenaar-Hilbers, J.P.A., Grosfeld, M.C., Rijkers, D.T.S., Moret, E.E., & Liskamp, R.M.J. Stabilization of peptide guinea pig myelin basic protein 72-85 by N-terminal acetylation-implications for immunological studies. Molecular Immunology / 2004 / 40 (13) / 943-948. PubMed PDF
Haas, P.J.A., Haas, C.J.C. de, Kleibeuker, W., Poppelier, M.J.J.G., Kessel, C.P.M. van, Kruijtzer, J.A.W., Liskamp, R.M.J., & Strijp, J.A.G. van. N-terminal residues of the chemotaxis inhibitory protein of Staphylococcus aureus are essential for blocking the formylated peptide receptor but not C5aR. Journal of Immunology / 2004 / 173 (9) / 5704-5711.
Joosten, J.A.F., Loimaranta, V., Appeldoorn, C.C.M., Haataja, S., Maate, F. ait el, Liskamp, R.M.J., Finne, J., & Pieters, R.J. Inhibition of Streptococcus Suis adhesion by dendritic galabiose compounds at low nanomolar concentration. Journal of Medicinal Chemistry / 2004 / 47 / 6499-6508. PubMed PDF [Graphical Abstract 2004]
Liskamp, R.M.J., & Kruijtzer, J.A.W. Peptide transformation leading to peptide-peptidosulfonamide hybrids and oligo peptidosulfonamides. Molecular diversity / 2004 / 8 / 79-87. PubMed PDF
Mol, N.J. de, Catalina Caballero, M.I., Fischer, M.J.E., Broutin, I., Maier, C.S., & Heck, A.J.R. Changes in structural dynamics of the Grb2 adaptor protein upon binding of phosphotyrosine ligand to its SH2 domain. Biochimica et Biophysica Acta / 2004 / 1700 (1) / 53-64. PubMed PDF
Monnee, M.C.F., Brouwer, A.J., & Liskamp, R.M.J. Synthesis, screening and evaluation of a combined library of tweezer- and tripodal synthetic receptors. QSAR & Combinatorial Science / 2004 / 23 / 546-559.
Nijenhuis, W.A.J., Wanders, N., Kruijtzer, J.A.W., Liskamp, R.M.J., Gispen, W.H., & Adan, R.A.H. Accelerating sensory recovery after sciatic nerve crush: non-selective versus melanocortin MC4 receptor-selective peptides. European Journal of Pharmacology / 2004 / 495 (2-3) / 145-152. PubMed PDF
Pieters, R.J. (2004). Interference with lectin binding and bacterial adhesion by multivalent carbohydrates and peptidic carbohydrate mimics. Trends in Glycoscience and Glycotechnology / 2004 / 16 / 243-254.
Planque, M.R.R. de, Rijkers, D.T.S., Fletcher, J.I., Liskamp, R.M.J., & Separovic, F. The alphaM1 segment of the nicotinic acetylcholine receptor exhibits conformational flexibility in a membrane environment. Biochimica et Biophysica Acta / 2004 / 1665 / 40-47. PubMed PDF
Planque, M.R.R. de, Rijkers, D.T.S., Liskamp, R.M.J., & Separovic, F. The alphaM1 transmembrane segment of the nicotinic acetylcholine receptor interacts strongly with model membranes. Magnetic Resonance in Chemistry / 2004 / 42 (2) / 148-54. PubMed PDF
Ridder, A.N.J.A., Spelbrink, R.E.J., Demmers, J.A.A., Rijkers, D.T.S., Liskamp, R.M.J., Brunner, J., Heck, A.J.R., Kruijff, B. de, & Killian, J.A. Photo-Crosslinking Analysis of Preferential Interactions between a Transmembrane Peptide and Matching Lipids. Biochemistry / 2004 / 43 / 4482-4489. PubMed PDF
Rijkers, D.T.S., Kruijtzer, J.A.W., Oostenbrugge, M. van, Ronken, E., Hartog, J.A.J. den, & Liskamp, R.M.J. Structure-activity studies on the corticotropin releasing factor antagonist astressin, leading to a minimal sequence necessary for antagonistic activity. ChemBioChem / 2004 / 5 / 340-348. [Graphical Abstract 2004]
Rijkers, D.T.S., Hartog, J.A.J. den, & Liskamp, R.M.J. Synthesis and biological activity of N-terminal lipidated and/or fluorescently labeled conjugates of astressin as corticotropin releasing factor antagonists. Bioorganic & Medicinal Chemistry / 2004 / 12 / 5099-5106. PubMed PDF [Graphical Abstract 2004]
Strandberg, E.J., Özdirekcan, S., Rijkers, D.T.S., Wel, P.C.A. van der, Koeppe II, R.E., Liskamp, R.M.J., & Killian, J.A. Tilt angles of transmembrane model peptides in oriented and non-oriented lipid bilayers as determined by 2H Solid State NMR. Biophysical Journal / 2004 / 86 / 3709-3721. PubMed PDF
Wang, X, Permentier, HP, Rink, R, Kruijtzer, J.A.W., Liskamp, R.M.J., Wösten, H.A.B., Poolman, B, & Robillard, G.T. Probing the self-assembly and the accompanying structural changes of hydrophobin SC3 on a hydrophobic surface by mass spectroscopy.Biophysical Journal / 2004 / 87 / 1919-1928.
Planque, M.R.R. de, Rijkers, D.T.S., Liskamp, R.M.J., & Separovic, F. The alphaM1 transmembrane segment of the nicotinic acetylcholine receptor interacts strongly with model membranes. Magnetic Resonance in Chemistry / 2004 / 42. PubMed PDF

Ph.D. Thesis:

Dekker, F.J.
Modulation of protein-protein interactions in signal transduction.
Molecular recognition of phosphopeptides
and phosphopeptidomimetics by SH2 domains.
14-06-2004 - UU Universiteit Utrecht (199 pag.).
Prom./coprom.: Liskamp, R.M.J., & Mol, N.J. de

Wels, B.
Synthesis of cyclic peptidomimetics as beta-turn mimetics.
17-05-2004 - UU Universiteit Utrecht (191 pag.).
Prom./coprom.: Liskamp, R.M.J.

Publications 2003

Ameijde, J. van, Liskamp, R.M.J. Synthesis of novel trivalent amino acid glycoconjugates based on the cyclotriverattrylene (CTV') scaffold. Organic & Biomolecular Chemistry / 2003 / 1 (15) / 2661-2669 PubMed
Arnusch, C.J., & Pieters, R.J. Solid phase synthesis of Vancomycine mimics. European Journal of Organic Chemistry / 2003 / 3131-3138. [Graphical Abstract 2003]
Autar, R., Khan, A.S., Schad, M., Hacker, J., Liskamp, R.M.J., & Pieters, R.J. Adhesion inhibition of F1C-fimbriated Escherichia coli and Pseudomonas aeruginosa PAK and PAO by multivalent carbohydrate ligands. ChemBioChem 4 / 2003 / 1317-1325. PubMed PDF [Graphical Abstract 2003]
Berg, A.J.J. van den, Halkes, S.B.A., Quarles van Ufford, H.C., Hoekstra, M.J., & Beukelman, C.J. A novel formulation of metal ions and citric acid reduces reactive oxygen species in vitro. Journal of wound care / 2003 / 12 / 413-417. PubMed
Catalina Caballero, M.I., Dekker, F.J., Liskamp, R.M.J., Versluis, C., Maier, C.S., & Heck, A.J.R. Structural analysis of high affinity divalent phosphopeptide hybrids of spleen tyrosine kinase. International Journal of Mass Spectrometry and Ion Processes / 2003 / 228 / 879-890.
Cerqueira, M. de Fatima Arauj, Watanadilok, R., Sonchaeng, P., Kijjoa, A., Pinto, M., Quarles van Ufford, H.C., Beukelman, C.J., & Nascimento, M.S.J. Clionasterol: A potent inhibitor of complement component C1. Planta Medica / 2003 / 69 / 171-174. PubMed
Chamorro Pérez, M.C., & Liskamp, R.M.J. Approaches to the solid phase of a cyclotriveratrylene scaffold-based tripodal library as potential artificial receptors. Journal of Combinatorial Chemistry / 2003 / 5 / 794-801. PubMed PDF
Dekker, F.J., Mol, N.J. de, Fischer, M.J.E., & Liskamp, R.M.J. Amino propynyl benzoic acid building block in rigid spacers of divalent ligands binding to the Syk SH2 domains with equally high affinity as the natural ligand. Bioorganic & Medicinal Chemistry Letters / 2003 / 13 / 1241-1244. PubMed PDF [Graphical Abstract 2003]
Dekker, F.J., Mol, N.J. de, Fischer, M.J.E., Kemmink, J., & Liskamp, R.M.J. Cyclic phosphopeptides for interference with Grb2 SH2 domain signal transduction prepared by ring-closing metathesis and phosphorylation. Organic & Biomolecular Chemistry / 2003 / 1 / 3297-3303. PubMed [Graphical Abstract 2003]
Dekker, F.J., Mol, N.J. de, Bultinck, P.R.E., Kemmink, J., Hilbers, H.W., & Liskamp, R.M.J. Role of solution conformation and flexibility of short peptide ligands that bind to the p56lck SH2 domain. Bioorganic & Medicinal Chemistry / 2003 / 11 / 941-949. [Graphical Abstract 2003]
Haan, E.C. de, Wauben, M.H.M., Wagenaar-Hilbers, J.P.A., Grosfeld-Stulemeyer, M.C., Rijkers, D.T.S., Moret, E.E., & Liskamp,R.M.J. Stabilization of peptide guinea pig myelin basic protein 72-85 by N-terminal acetylation - implications for immunological studies. Molecular Immunology / 2003 / 40 / 943-948. PubMed PDF
Kol, M.A., Laak, A.N.C. van, Rijkers, D.T.S., Killian, J.A., Kroon, A.I.P.M. de, & Kruijff, B. de. Phospholipid flop induced by transmembrane peptides in model membranes is modulated by lipid composition. Biochemistry / 2003 / 42 / 231-237. PubMed PDF
Koorbanally, N.A., Randrianarivelojosia, M., Mulholland, D.A., Quarles van Ufford, H.C., & Berg, A.J.J. van den. Chalcones from the seed of Cedrelopsis grevei (Ptaeroxylaceae).Phytochemistry / 2003 / 62 / 1225-1229. PubMed PDF
Kopitz, J., André, S., Reitzenstein, C. Von, Versluis, C., Kaltner, H., Pieters, R.J., Wasano, K., Kuwabara, I., Liu, F-T., Cantz, M., Heck, A.J.R., & Gabius, H-J. (2003). Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells. Oncogene / 2003 / 22 / 6277-6288. PubMed PDF
Luten, J., Steenis, J.H van, Someren, R. van, Kemmink, J., Schuurmans-Nieuwenbroek, N.M.E., Koning, G.A., Crommelin, D.J.A., Nostrum, C.F. van, & Hennink, W.E. Water-soluble biodegradable cationic polyphosphazenes for gene delivery. Journal of Controlled Release / 2003 / 89 / 483-497. PubMed PDF
Liskamp, R.M.J., Kruijtzer, J.A.W. Peptide transformation leading to peptide-peptodosulfonamide hybrids and oligo peptidosulfonamides. Molecular Diversity / 2003 (in press) Pubmed PDF
Merkx, N.S.M., Rijkers, D.T.S., Kemmink, J., & Liskamp, R.M.J.Chemoselective coupling of peptide fragments using the Staudinger ligation. Tetrahedron Letters / 2003 / 44 / 4515-4518. [Graphical Abstract 2003]
Mol, N.J. de, Fischer, M.J.E. Applications of surface plasmon resonance (SPR) in ligand - receptor-binding studies: Affinity, kinetics and thermodynamics. recent Research development Analytical Biochemistry / 2003 / 3 / 1-20
Nijenhuis, W.A.J., Kruijtzer, J.A.W., Wanders, N., Vrinten, D.H., Garner, K.M., Schaaper, W.M.M., Meloen, R.H., Gispen, W.H., Liskamp, R.M.J., & Adan, R.A.H. Discovery and in vivo evaluation of new melanocortin-4 receptor-selective peptides. Peptides / 2003 / 24 (2) / 271-280. PubMed PDF
Rijkers, D.T.S., Kruijtzer, J.A.W., Oostenbrugge, M. van, Ronken, E., Hartog, J.A.J. den, Liskamp, R.M.J. Structure-Activity Studies on the Corticotropin Releasing Factor Antagonist Astressin leading to Minimal Sequence necessary for Antagonistic Activity. ChemBioChem / 2003 (in press) PubMed PDF
Vrasidas, I., Andre, S., Valentini, P., Bock, C., Lensch, M., Kaltner, H., Liskamp, R.M.J., Gabius, H-J., & Pieters, R.J. Rigidified multivalent lactose molecules and their interactions with mammalian galectins: a route to selective inhibitors. Organic & Biomolecular Chemistry / 2003 / 1 / 803-810. PubMed [Graphical Abstract 2003]

Ph.D. Thesis:

Haan, E.C. de.
Peptide modification in T cell immunology - from molecule to
animal.
06-10-2003 - UU Universiteit Utrecht (126 pag.).
Prom./coprom.: Liskamp, R.M.J., Moret, E.E., & Wauben, M.H.M.

Vrasidas, I.
Synthesis of carbohydrate functionalized dendrimers and their
interactions with lectins.
23-05-2003 - UU Universiteit Utrecht (184 pag.).
Prom./coprom.: Liskamp, R.M.J., & Pieters, R.J.

Publications 2002

Ameijde, J. van, Albada, H.B. & Liskamp, R.M.J. A convenient preparation of several N-linked glycoamino acid building blocks for efficient solid-phase synthesis of glycopeptides. Journal of the Chemical Society. Perkin transactions I, organic and bio-organic chemistry /2002 / 1042-1049.
Bast, A., Chandler, R.F., Choy, P.C., Delmulle, L.M., Gruenwald, J., Halkes, S.B.A., Keller, K., Koeman, J.H., Peters, P., Przyrembel, H., Ree, E.M. de, Renwick, A.G. & Vermeer, I.T.M. Botanical health products, positioning and requirements for effective and safe use. Environmental Toxicology and Pharmacology / 2002 / 12 / 195-211.
Beukelman, C.J., Worm, E. van den, Quarles van Ufford, H.C., Kroes, B.H. & Berg, A.J.J. van den. Discovery of new anti-inflammatory drugs from plant origin Annals of Gastroenterology / 2002 / 15 / 320-323.
Bosch, M.A.A.J. van den, Wittebol, S., Dijk, H. van & Kramer, M.H.H.Hypocalcemic tetany as an early sign of DiGeorge syndrome in an adult woman. The American Journal of Medicine / 2002 / 112 / 161-162. PubMed
Branderhorst, H.M., Kemmink, J., Liskamp, R.M.J. & Pieters, R.J. Catalytic conversions of diazosugars. Tetrahedron Letters / 2002 / 43 / 9601-9603. [Graphical Abstract 2002]
Bultinck, P.R.E., Augustynen, S., Hilbers, H.W., Moret, E.E. & Tollenaere, J.P.A.E. Generate: A program for 3-D structure generation and conformational analysis of peptides and peptidomimetics. Journal of computational chemistry / 2002 / 23 / 746-754. PubMed PDF
Dekker, F.J., Mol, N.J. de, Ameijde, J. van, Fischer, M.J.E., Ruijtenbeek, R., Redegeld, F.A.M. & Liskamp, R.M.J. Replacement of the intervening amino acid sequence of a Syk-binding diphosphopeptide by a nonpeptide spacer with preservation of high affinity. ChemBioChem / 2002 / 2(3) / 238-242. [Graphical Abstract 2002]
Demmers, J.A.A., Rijkers, D.T.S., Haverkamp, J., Killian, J.A. & Heck, A.J.R. Factors affecting gas-phase deuterium scrambling in peptide ions and their implications for protein structure determination. Journal of the American Chemical Society / 2002 / 124 / 11191-11198. PubMedPDF
Duyl, B.Y. van, Rijkers, D.T.S., Kruijff, B. de & Killian, J.A. Influence of hydrophobic mismatch and palmitoylation on the association of transmembrane alpha-helical peptides with detergent-resistant membranes. FEBS letters / 2002 / 523 / 79-84. PubMed PDF
Haan, E.C. de, Wauben, M.H.M., Grosfeld-Stulemeyer, M.C., Kruijtzer, J.A.W., Liskamp, R.M.J. & Moret, E.E. Major histocompatibility complex class II binding characteristics of peptoid-peptide hybrids. Bioorganic & Medicinal Chemistry / 2002 / 10 / 1939-1945. PubMed PDF [Graphical Abstract 2002]
Halkes, S.B.A., Vrasidas, I., Rooijer, G.R., Berg, A.J.J. van den, Liskamp, R.M.J. & Pieters, R.J. Synthesis and biological activity of polygalloyl-dendrimers as stable tannic acid mimics. Bioorganic & Medicinal Chemistry Letters / 2002 / 12 / 1567-1570. PubMed PDF [Graphical Abstract 2002]
Halkes, S.B.A., Berg, A.J.J. van den, Hoekstra, M.J., Pont, J.S. du & Kreis, R.W. Transaminase and alkaline phosphatase activity in the serum of burn patients treated with highly purified tannic acid. Burns / 2002 / 28 / 449-453. PubMed
Houben, R.J.T.J., Rijkers, D.T.S., Stanley, T.B., Acher, F., Azerad, R., Käkönen, S-M., Vermeer, C. & Soute, B.A.M. Characteristics and composition of the vitamin K-dependent gamma-glutamyl carboxylase-binding domain on osteocalcin. Biochemical Journal / 2002 / 364 / 323-328. PubMed
Jong, R. de, Rijkers, D.T.S. & Liskamp, R.M.J. Automated solid-phase synthesis and structural investigation of beta-peptidosulfonamides and beta-peptidosulfonamide/beta-peptide hybrids: beta-peptidosulfonamide and beta-peptide foldamers are two of a different kind. Helvetica chimica acta / 2002 / 85 / 4230-4243.
Koorbanally, N.A., Randrianarivelojosia, M., Mulholland, D.A., Quarles van Ufford, H.C. & Berg, A.J.J. van den Bioactive constituents of cedrelopsis microfoliata. Journal of Natural Products / 2002 / 65 / 1349-1352. PubMed PDF
Kuipers, S., Aerts, P.C., Sjoholm, A.G., Harmsen, M. & Dijk, H. van. A hemolytic assay for the estimation of functional mannose-binding lectin levels in human serum. Journal of Immunological Methods / 2002 / 68 / 149-157. PubMed PDF
Leeuwen, S.H. van, Quaedflieg, P.J.L.M., Broxterman, Q.B. & Liskamp, R.M.J. Synthesis of amides from unprotected amino acids by a simultaneous protection-activation strategy using dichlorodialkyl silanes. Tetrahedron Letters / 2002 / 43 / 9203-9207.
Mijssen, S., Dijk, H. van, Verseyden, C., Erkelens, D.W. & Castro Cabezas, M. Delayed and exaggerated postprandial complement component C3 response in familial combined hyperlipidemia. Arteriosclerosis Thrombosis and Vascular Biology / 2002 / 22 / 811-816. PubMedPDF
Mol, N.J. de, Gillies, M.B. & Fischer, M.J.E. Experimental and calculated shift in pKa upon binding of phosphotyrosine peptide to the SH2 domain of p56lck. Bioorganic & Medicinal Chemistry / 2002 / 10 / 1477-1482. [Graphical Abstract 2002]
Mulholland, D.A., Kotsos, M., Mahomed, H.A., Koorbanally, N.A., Randrianarivelojosia, M., Quarles van Ufford, H.C. & Berg, A.J.J. van den. Coumarins from cedrelopsis grevei (Ptaeroxylaceae). Phytochemistry /2002 / 61 / 919-922. PubMed PDF
Opatz, T. & Liskamp, R.M.J. Synthesis and screening of libraries of synthetic tripodal receptor molecules with three different amino acid or peptide arms: identification of iron binders. Journal of Combinatorial Chemistry / 2002 / 4 / 275-284. PubMed PDF
Planque, M.R.R. de, Boots, J.-W.P., Rijkers, D.T.S., Liskamp, R.M.J., Greathouse, D.V. & Killian, J.A. The effects of hydrophobic mismatch between phosphatidylcholine bilayers and transmembrane alpha-helical peptides depend on the nature of interfacially exposed aromatic and charged residues. Biochemistry /2002 / 41 / 8396-8404. PubMed PDF
Rijkers, D.T.S., Vugt, H.H.R. van, Jacobs, J.J.F. & Liskamp, R.M.J. A convenient synthesis of azido peptides by post-assembly diazo transfer on the solid phase applicable to large peptides. Tetrahedron Letters / 2002 / 43 / 3657-3660.
Rijkers, D.T.S., Hartog, J.A.J. den & Liskamp, R.M.J. An optimized solid phase synthesis strategy-including on-resin lactamization- of astressin, its retro-, inverso- and retro-inverso isomers as corticotropin releasing factor antagonists. Biopolymers / 2002 / 63 / 141-149. PubMed PDF
Rijkers, D.T.S., Höppener, J.W.M., Posthuma, G., Lips, C.J.M & Liskamp, R.M.J. Inhibition of amyloid fibril formation of human amylin by N-alkylated amino acid and alpha-hydroxy acid residue containing peptides.Chemistry-A European Journal / 2002 / 8(18) / 4285-4291. PubMed PDF
Rinia, H.A., Boots, J.W.P., Rijkers, D.T.S., KIK, R.A., Snel, M.M.E., Demel, R.A., Killian, J.A., Eerden, J.P.J.M. van der & Kruijff, B. de. Domain formation in phosphatidylcholine bilayers containing transmembrane peptides: specific effects of flanking residues. Biochemistry / 2002 / 41 / 2814-2824.PubMed PDF
Ruijtenbeek, R., Versluis, C., Heck, A.J.R., Redegeld, F.A.M., Nijkamp, F.P. & Liskamp, R.M.J. Characterization of a phosphorylated peptide and peptoid and peptoid-peptide hybrids by mass spectrometry. Journal of Mass Spectrometry / 2002 / 37 / 47-55. PubMed PDF
Rump, E.T., Rijkers, D.T.S., Hilbers, H.W., Groot, P.G. de & Liskamp, R.M.J. Cyclotriveratylene (CTV) as a new chiral triacid scaffold capable of inducing triple helix formation of collagen peptides containing either a native sequence or Pro-Hyp-Gly repeats. Chemistry / 2002 / 8 / 4613-4621. PubMed PDF
Strandberg, E.J., Morein, S., Rijkers, D.T.S., Liskamp, R.M.J., Wel, P.C.A. van der & Killian, J.A. Lipid dependence of membrane anchoring properties and snorkeling behavior of aromatic and charged residues in transmembrane peptides. Biochemistry / 2002 / 41 / 7190-7198. PubMed PDF
Vrasidas, I., Kemmink, J., Liskamp, R.M.J. & Pieters, R.J. Synthesis and cholera toxin binding properties of a lactose-2-aminothiazoline conjugate. Organic letters / 2002 / 4 / 1807-1808. PubMed PDF [Graphical Abstract 2002]
Wels, B., Kruijtzer, J.A.W. & Liskamp, R.M.J. Synthesis of cyclic (alpha2beta)-tripeptides as potential peptide turn mimetics. Organic letters / 2002 / 4 / 2173-2176.

Ph.D. Thesis:

Ameijde, J. van.
Design, synthesis and evaluation of porin blocking compounds.
30-10-2002 - Universiteit Utrecht, 164 pp.
((Co-)promot.: Prof.dr. R. M. J. Liskamp).

Monnee, M.C.F.
Bio-inspired artificial receptors.
Combinatorial synthesis, screening and evaluation of tweezers
and tripods.
22-10-2002 - Universiteit Utrecht, 192 pp.
((Co-)promot.: Prof.dr. R. M. J. Liskamp).

Publications 2001

André, S., Pieters, R.J., Vrasidas, I., Kaltner, H., Kuwabara, I., Liu, F-T., Liskamp, R.M.J. & Gabius, H-J. Wedgelike glycodendrimers as inhibitors of binding of mammalian galectins to glycoproteins, lactose maxiclusters, and cell surface glycoconjugates. ChemBioChem / 2001 / 2 / 822-830 PubMed PDF [Graphical Abstract 2001]
Bloemink, M.J., Kemmink, J., Dentten, E., Muskett, F.W., Whelan, A., Sheikh, A., Hewinson, G., Williamson, R.A. & Carr, M.D. Sequence-specific assignment and determination of the secondary structure of the 163-residue M. tuberculosis and M. bovis antigenic protein mpb70. Journal of Biomolecular NMR / 2001 / 20 / 185-186.
Boon, G., Langenaeker, W., Proft, F. de, Winter, H. de, Tollenaere, J.P.A.E. & Geerlings, P. Systematic study of the quality of various quantum similarity descriptors. Use of the autocorrelation function and principal component analysis. Journal of Physical Chemistry A / 2001 / 105 / 8805-8814.
Brouwer, A.J., Mulders, S.J.E. & Liskamp, R.M.J. Convergent synthesis and diversity of amino acid based dendrimers.European Journal of Organic Chemistry / 2001 / 1903-1915.
Fischer, M.J.E., Kuipers, C., Hofkes, R.P., Hofmeyer, L.J.F., Moret, E.E. & Mol, N.J. de. Exploring computational lead optimisation with affinity constants obtained by surface plasmon resonance for the interaction of PorA epitope peptides with antibody against Neisseira meningitidis. Biochimica et Biophysica Acta-General Subjects / 2001 / 1568 / 205-215. PubMed PDF
Haan, E.C. de, Wauben, M.H.M., Grosfeld-Stulemeyer, M.C. & Moret, E.E. Structure-based design and evaluation of MHC class II binding peptides. Biologicals / 2001 / 29 / 289-292. PubMed PDF
Halkes, S.B.A., Berg, A.J.J. van den, Hoekstra, M.J., Pont, J.S. du & Kreis, R.W. The use of tannic acid in the local treatment of burn wounds: intriguing old and new perspectives. Wounds-Compendium of Clinical Research and Practice / 2001 / 13 / 144-158.
Halkes, S.B.A., Berg, A.J.J. van den, Hoekstra, M.J., Pont, J.S. du & Kreis, R.W. Treatment of burns: new perspectives for highly purified tannic acid? Burns / 2001 / 27 / 299-300. PubMed
Huls, G., Gestel, D., Linden, J. van der, Moret, E.E. & Logtenberg, T. Tumor cell killing by in vitro affinity-matured recombinant human monoclonal antibodies. Cancer Immunology and Immunotherapy / 2001 / 50 / 163-171. PubMed
Jong, S.J. de, Arias, E.R., Rijkers, D.T.S., Nostrum, C.F. van, Kettenes-van den Bosch, J.J. & Hennink, W.E. New insights into the hydrolytic degradation of poly(lactic acid): participation of the alcohol terminus. Polymer / 2001 / 42 / 2795-2802
Kol, M.A., Kroon, A.I.P.M. de, Rijkers, D.T.S., Killian, J.A. & Kruijff, B. de. Membrane-spanning peptides induce phospholipid flop: a model for phospholipid translocation across the inner membrane of E. coli.Biochemistry / 2001 / 40 / 10500-10506. PubMed PDF
Monnee, M.C.F., Brouwer, A.J., Verbeek, L.M., Wageningen, A.M.A. van & Liskamp, R.M.J. Bio-inspired synthetic receptor molecules towards mimicry of Vancomycin. Bioorganic & Medicinal Chemistry Letters / 2001 / 11 / 1521-1525. PubMed PDF
Opatz, T. & Liskamp, R.M.J. A selectively deprotectable triazacyclophane scaffold for the construction of artificial receptors. Organic Letters / 2001 / 3 / 3499-3502. PubMed PDF
Pieters, R.J., Lutje Spelberg, J.H., Kellogg, R.M. & Janssen, D.B. The enantioselectivity of haloalkane dehalogenases. Tetrahedron Letters / 2001 / 42 / 469-471.
Planque, M.R.R. de, Goormaghtigh, E., Greathouse, D.V., Koeppe, R.E., Kruijtzer, J.A.W., Liskamp, R.M.J., Kruijff, B. de & Killian, J.A. Sensitivity of single membrane-spanning alpha-helical peptides to hydrophobic mismatch with a lipid bilayer: effects on backbone structure, orientation, and extent of membrane incorporation. Biochemistry / 2001 / 40 / 5000-5010.
Ruijtenbeek, R., Kruijtzer, J.A.W., Wiel, W. van der, Fischer, M.J.E., Flück, M., Redegeld, F.A.M., Liskamp, R.M.J. & Nijkamp, F.P. Peptoid - peptide hybrids that bind Syk SH2 domains involved in signal transduction. ChemBioChem / 2001 / 2 / 171-179. PubMed PDF
Scholten, W.K. & Halkes, S.B.A. Introducing a system for the assessment of quality, safety, and efficacy of herbal medicinal products in the Netherlands. Drug Information Journal / 2001 / 35 / 461-468.
Vrasidas, I., Mol, N.J. de, Liskamp, R.M.J. & Pieters, R.J. Synthesis of lactose dendrimers and multivalency effects in binding to the cholera toxin B subunit. European Journal of Organic Chemistry / 2001 / 4685-4692. [Graphical Abstract 2001]
Worm, E. van den, Beukelman, C.J., Berg, A.J.J. van den, Kroes, B.H., Labadie, R.P. & Dijk, H. van. Effects of methoxylation of apocynin and analogs on the inhibition of reactive oxygen species production by stimulated human neutrophils. European Journal of Pharmacology / 2001 / 433 / 225-230. PubMed PDF

Ph.D. thesis:

Gillies, M.B.
Computational studies of protein-ligand molecular recognition.
19-04-2001 - Utrecht ľ�ϸ��Ӱ��
(Co-)promot.: Prof.dr. J. P. A. E. Tollenaere & Dr. E. E. Moret.

Ruijtenbeek, R.
Peptoids in the development of peptidomimetic inhibitors of
Syk SH2 domains.
30-05-2001 - Utrecht ľ�ϸ��Ӱ��
(Co-)promot.: Prof.dr. R. M. J. Liskamp, Prof.dr. F. P. Nijkamp &
Dr. F. A. M. Redegeld.

Worm, E. van den.
Investigations on apocynin, a potent NADPH oxidase inhibitor.
11-05-2001 - Utrecht ľ�ϸ��Ӱ��
(Co-)promot.: Prof.dr. R. P. Labadie, Prof.dr. H. van Dijk,
Dr. C.J. Beukelman & Dr. A. J. J. van den Berg.

Publications 2000

Ameijde, J. van & Liskamp, R.M.J. Peptidomimetic building blocks for the synthesis of sulfonamide peptoids. Tetrahedron Letters/ 2000 / 41 / 1103-1106.
Barbakadze, V., Kemertelidze, E., Targamadze, I., Shashkov, A.S., Usov, A.I., Kroes, B.H., Berg, A.J.J. van den & Labadie, R.P. Partial characterization of a new anticomplementary and antioxidative dihydroxycinnamate-derived polymer from Symphytum asperum Lepech. Trans-Caucasian Journal of Immunology / 2000 / 2 / 27-31.
Brouwer, A.J., Monnee, M.C.F. & Liskamp, R.M.J. An efficient synthesis of N-protected beta-aminoethanesulfonyl chlorides: versatile building blocks for the synthesis of oligopeptidosulfonamides. Synthesis-Stuttgart / 2000 / 11 / 1579-1584.
Brouwer, A.J., Linden, H.J. van der & Liskamp, R.M.J. Combinatorial chemistry for ligand development in catalysis: synthesis and catalysis screening of peptidosulfonamide tweezers on the solid phase. European Journal of Organic Chemistry / 2000 / 65 / 1750-1757.
Engels, M.F.M., Thielemans, T., Verbinnen, D., Tollenaere, J.P.A.E. & Verbeeck, R. CerBerus: A system supporting the sequential screening process. Journal of Chemical Information and Computer Sciences / 2000 / 40 / 241-245. PubMed
Lowik, D.W.P.M. & Liskamp, R.M.J. Synthesis of alpha- and beta-substituted aminoethane sulfonamide arginine-glycine mimics. European Journal of Organic Chemistry / 2000 / 1219-1228.
Mol, N.J. de, Plomp, E, Fischer, M.J.E. & Ruijtenbeek, R. Kinetic analysis of the mass transport limited interaction between the tyrosine kinase lck SH2 domain and a phosphorylated peptide studied by a new cuvette-based surface plasmon resonance instrument. Analytical Biochemistry / 2000 / 279 / 61-70.
Monnee, M.C.F., Marijne, M.F., Brouwer, A.J. & Liskamp, R.M.J. A practical solid phase synthesis of oligopeptidosulfonamide foldamers. Tetrahedron Letters / 2000 / 41 / 7991-7995.
Nardi, F., Kemmink, J., Sattler, M. & Wade, R.C. The cis-proline(i-1)-aromatic(i) interaction: folding of the Ala-cisPro-Tyr peptide characterized by NMR and theoretical approaches. Journal of Biomolecular NMR / 2000 / 17 / 63-77.
Pieters, R.J. Synthesis and binding studies of carboxylate binding pocket analogs of Vancomycin. Tetrahedron Letters / 2000 / 41 / 7541.
Reichwein, J.F. & Liskamp, R.M.J. Synthesis of cyclic dipeptides by Ring-Closing Metathesis. European Journal of Organic Chemistry / 2000 / 2335-2344.
Reichwein, J.F., Versluis, C. & Liskamp, R.M.J. Synthesis of cyclic peptides by Ring-Closing Metathesis. European Journal of Organic Chemistry / 2000 / 65 / 6187-6195. PubMed
Smit, H.F., Kroes, B.H., Berg, A.J.J. van den, Wal, D. van der, Worm, E. van den, Beukelman, C.J., Dijk, H. van & Labadie, R.P. Immunomodulatory and anti-inflammatory activity of Picrorhiza scrophulariiflora. Journal of Ethnopharmacology / 2000 / 73 / 101-109. PubMed PDF
Smit, H.F., Berg, A.J.J. van den, Kroes, B.H., Beukelman, C.J., Quarles van Ufford, H.C., Dijk, H. van & Labadie, R.P. Inhibition of T-lymphocyte proliferation by cucurbitacins from Picrorhiza scrophulariaeflora. Journal of Natural Products / 2000 / 63 / 1300-1302. PubMed PDF

Ph.D. thesis:

Boeijen, A.
Combinatorial chemistry of Urea peptidomimetics.
19-05-2000 - Utrecht ľ�ϸ��Ӱ��.
(Co-)promot.: Prof.dr. R. M. J. Liskamp

Reichwein, J.F.
Synthesis of cyclic N-alkylated peptides by Ring-Closing
Metathesis.
19-06-2000 - Utrecht ľ�ϸ��Ӱ��.
(Co-) promot.: Prof.dr. R. M. J. Liskamp.

Smit, H.F.
Picrorhiza scrophulariiflora, from traditional use
to immunomodulatory activity.
07-06-2000 - Utrecht ľ�ϸ��Ӱ��.
(Co-) promot.: Prof.dr. R. P. Labadie, Prof.dr. H. van Dijk &
Dr. B. H. Kroes.

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