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Membrane proteins are among the most challenging systems to study with experimental techniques in the structural biology field. The increasing number of deposited structures of membrane proteins has opened the route to modeling their complexes by methods such as computational docking.

The Utrecht computational structural biology group () has developed a new protocol for the modeling of membrane-associated protein assemblies, which successfully integrates a simulated membrane calculated by the database into a first docking step by with a flexible final refinement with . This protocol should shed light on the still dark fraction of the interactome consisting of membrane proteins and will be extremely useful for drug discovery, antibody design and personalized medicine.